基于数据挖掘分析腰椎间盘突出症中药外用专利方用药规律及毒性药物使用
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R274.9

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国家中医药管理局全国名老中医专家传承工作室建设项目(国中医药人教发〔2014〕20号)


Analysis of Medication Rules and Use of Toxic Herbs in Patented External Chinese Herbal Prescriptions for Lumbar Disc Herniation Based on Data Mining
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    摘要:

    目的:基于数据挖掘技术分析腰椎间盘突出症中药外用专利方的用药规律及毒性药物的使用。方 法:检索国家知识产权局专利数据库,收集整理自建库至2023年9月13日治疗腰椎间盘突出症的中药外用方, 运用Microsoft Excel 2019、SPSS Statistics 26、Cytoscape 3.8.2、SPSS Modeler 18.0进行频数分析、关联规则分 析、聚类分析、绘制四气五味归经雷达图、中药功效饼状图、共现网络图。结果:共纳入134个专利方,涉及 429味中药,频数≥40的药物有红花、没药、乳香、透骨草、川乌、川芎、当归,毒性中药高频的药物有川乌、 草乌、土鳖虫、全蝎。药物四气以温性为主,五味以苦、辛为主,归经以肝经为主,肺、脾、肾经次之,毒性 中药同前。功效以祛风湿、清热、活血化瘀、补虚为主;关联规则分析得出“没药→乳香”支持度最高;中药 新处方有4组。结论:中药外用治疗腰椎间盘突出症主要以血瘀型以及寒湿型为主,治法以活血化瘀和祛风除 湿为主,结合证型辅以补虚、清热,重在治标。

    Abstract:

    Abstract:Objective:To analyze the medication rules and use of toxic herbs in patented external Chinese herbal prescriptions for lumbar disc herniation based on data mining technology. Methods: The patent database of the National Intellectual Property Administration was searched to collect external Chinese herbal prescriptions for lumbar disc herniation from the establishment of the database to September 13,2023. Microsoft Excel 2019,SPSS Statistics 26,Cytoscape 3.8.2,and SPSS Modeler 18.0 were used for frequency analysis,association rule analysis,clustering analysis, drawing radar charts of four properties, five flavors, and channel entries, pie charts of Chinese herbal effects, and co-occurrence network diagrams. Results: A total of 134 patented prescriptions involving 429 Chinese medicinal herbs were included. The herbs with a frequency ≥ 40 included Carthami Flos, Myrrha, Olibanum, Speranskiae Tuberculatae Herba, Aconiti Radix, Chuanxiong Rhizoma and Angelicae Sinensis Radix. The highfrequency toxic herbs included Aconiti Radix, Aconiti Kusnezoffii Radix, Eupolyphaga Steleophaga and Scoppio. In terms of four qi,the herbs were mainly warm;in terms of five flavors,they were mainly bitter and acrid,and in terms of channel entries,they mainly belonged to the liver channel,followed by the lung,spleen,and kidney channels. The toxic herbs were similar to the above. The main effects were dispelling wind-damp,clearing heat,invigorating blood and dissolving stasis, and supplementing deficiency. Association rule analysis showed that the pair "Myrrha→ Olibanum" had the highest support. Clustering analysis yielded four new prescriptions of Chinese herbs. Conclusion: External application of Chinese herbs for lumbar disc herniation mainly targets on blood stasis syndrome and cold-damp syndrome, with the main treatments being invigorating blood and dissolving stasis and dispelling wind-damp. It is combined by supplementing deficiency and clearing heat according to syndrome types,focusing on treating the branch.

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魏燊,丘明旺,王博,吴毅坤,王继红.基于数据挖掘分析腰椎间盘突出症中药外用专利方用药规律及毒性药物使用[J].新中医,2025,57(7):13-20

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  • 在线发布日期: 2025-04-09
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