当归芍药散加味联合西药治疗气虚血瘀型产后恶露不尽临床研究
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R271.43

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Clinical Study on Modified Danggui Shaoyao Powder Combined with Western Medicine for Postpartum Lochiorrhea of Qi Deficiency and Blood Stasis Type
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    摘要:

    目的:观察当归芍药散加味联合缩宫素加抗生素治疗产后恶露不尽气虚血瘀证临床疗效。方法: 选取2021年4月—2024年4月虞城县人民医院收治的86例产后恶露不尽气虚血瘀证患者,按随机数字表法分 为观察组及对照组各43例,对照组剔除1例,最终对照组42例、观察组43例纳入研究。2组均接受常规治疗, 对照组给予缩宫素联合头孢拉定胶囊治疗,观察组在对照组治疗基础上联合当归芍药散加味治疗,2组均治疗 7 d。治疗结束后第15天比较2组临床疗效。于治疗前、治疗7 d后,比较2组中医证候积分、子宫血流动力学 指标[子宫收缩期动脉峰值流速(PSV)、阻力指数(RI)、博动指数(PI)]。比较2组血性恶露持续时间,记 录并计算治疗第1天起至治疗结束后第7天的血性恶露量。记录治疗期间不良反应发生情况。结果:观察组总 有效率95.34%(41/43),高于对照组78.57%(33/42)(P<0.05)。治疗7 d后,2组中医证候积分均较治疗前降 低,观察组中医证候积分低于对照组(P<0.05);2 组PI、RI均较治疗前降低,观察组PI、RI均低于对照 组(P<0.05);2组PSV均较治疗前加快,观察组PSV快于对照组(P<0.05)。观察组血性恶露持续时间短于 对照组,治疗第1天起至治疗结束后第7天的血性恶露量少于对照组(P<0.05)。2组治疗期间不良反应发生率 比较,差异无统计学意义(P>0.05)。结论:当归芍药散加味联合缩宫素加抗生素治疗产后恶露不尽气虚血瘀 证可有效提高疗效,缓解临床症状,促进子宫恢复,改善子宫血流灌注情况,安全性高。

    Abstract:

    Abstract:Objective:To observe the clinical effect of the combination use of modified Danggui Shaoyao Powder, Oxytocin and Antibiotics on postpartum lochiorrhea with syndrome of qi deficiency and blood stasis. Methods:A total of 86 patients with postpartum lochiorrhea admitted to the People's Hospital of Yucheng County from April 2021 to April 2024 were selected and divided into the observation group and the control group according to the random number table method, with 43 cases in each group. With one case being excluded from the control group, finally 42 cases and 43 cases were respectively included in the control group and the observation group for study. Both groups received conventional treatment. The control group was additionally treated with Oxytocin combined with Cefradine Capsules, and the observation group was additionally treated with modified Danggui Shaoyao Powder based on the treatment of the control group. Both groups were treated for seven days. On the 15th day after treatment, the clinical effects were compared between the two groups. Before treatment and after seven days of treatment,the traditional Chinese medicine syndrome scores and uterine hemodynamics indexes [pulsitility index (PI) of uterine artery during systole, resistance index (RI) and peak systolic velocity (PSV)] were compared between the two groups. The duration of bloody lochia was compared between the two groups, and the amount of bloody lochia from the first day of treatment to the seventh day after treatment was recorded and calculated. The adverse reactions during treatment were recorded. Results:The total effective rate was 95.34% (41/43) in the observation group, higher than that of 78.57% (33/42) in the control group (P<0.05). After seven days of treatment, the traditional Chinese medicine syndrome scores in the two groups were reduced when compared with those before treatment,and the above scores in the observation group were lower than those in the control group (P<0.05);the RI and PI in the two groups were dwindled when compared with those before treatment,and RI and PI in the observation group were lower than those in the control group (P<0.05). The PSV in the two groups was fastened when compared with that before treatment,and the PSV in the observation group was faster than that in the control group (P<0.05). The duration of bloody lochia in the observation group was shorter than that in the control group, and the amount of bloody lochia from the first day of treatment to the seventh day after the end of treatment was less than that in the control group (P<0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions during treatment between the two groups (P>0.05). Conclusion:The combination use of modified Danggui Shaoyao Powder, Oxytocin and Antibiotics can effectively improve the curative effect on postpartum lochiorrhea with syndrome of qi deficiency and blood stasis, relieve the symptoms, promote the recovery of the uterus,and enhance the uterine blood flow perfusion with great safety.

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洪磊,宋圣英,洪娟.当归芍药散加味联合西药治疗气虚血瘀型产后恶露不尽临床研究[J].新中医,2025,57(7):40-45

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  • 在线发布日期: 2025-04-09
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