Abstract： Objective： To investigate the clinical effects of Jianpi Shugan Prescription combined with cognitive behavioral therapy （CBT） in treating postpartum depression （PPD）. Methods：A total of 86 patients with PPD treated at the Nanyang Fourth People's Hospital from June 2022 to June 2023 were selected，according to the treatment method， it was divided into a control group （39 cases） and a study group （47 cases）. The control group was treated with citalopram combined with CBT，while the study group was treated with Jianpi Shugan Prescription combined with CBT. The treatment duration was eight weeks for both groups. Levels of neurotransmitters [serotonin （5-HT） ， norepinephrine （NE）， and dopamine （DA）]， SF-36 scores [social functioning （SF）， mental health （MH）， and physical functioning （PF）]， cognitive function [Montreal Cognitive Assessment （MoCA） scores]， depressive status [Edinburgh Postnatal Depression Scale （EPDS） scores]，infant caregiving ability （care knowledge，care ability，and care skills） scores， Pittsburgh Sleep Quality Index （PSQI） scores （sleep efficiency， sleep latency， and daytime dysfunction）， and levels of progesterone （P）， estradiol （E2）， and cortisol （COR） were compared between the two groups before and after treatment. Results： After treatment， levels of neurotransmitters （NE， 5-HT， and DA）， SF-36 scores（ SF，MH，and PF），MoCA scores，infant caregiving ability scores（ care knowledge，care ability，and care skills）， and levels of P and E2 were increased in the two groups compared to those before treatment （P＜0.05）. Sleep efficiency scores sleep time scores， and daytime dysfunction scores， EPDS scores， and COR levels were decreased， in both groups compared to those before treatment （P＜0.05）. The study group showed higher levels of neurotransmitters （NE， 5-HT， and DA）， SF-36 scores （SF， MH， and PF）， MoCA scores， infant caregiving ability scores （care knowledge， care ability， and care skills）， and levels of P and E2 than the control group （P＜ 0.05）. The study group had lower sleep efficiency scores，lower sleep time scores，lower daytime dysfunction scores， lower EPDS scores，and lower COR levels than the control group （P＜0.05）. Conclusion：The combination of Jianpi Shugan Prescription and CBT shows better therapeutic effects in treating PPD. It can improve cognitive function， alleviate depression symptoms，enhance infant caregiving ability，improve sleep quality，and regulate hormone levels.