Abstract： Objective： To observe the clinical effects of GUO's Bianxue Prescription in treating internal hemorrhoids with hematochezia of damp-heat pouring downward type. Methods： A total of 80 patients with internal hemorrhoids with hematochezia of damp-heat pouring downward type admitted to Jiaxing Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University from October 2022 to December 2023 were selected and randomly divided into a control group and an observation group according to the random number table method， with 40 cases in each group. No cases were excluded or lost during the study period. The control group was treated with Mayinglong Musk Hemorrhoids Ointment， while the observation group was treated with GUO's Bianxue Prescription. The clinical efficacy of the two groups was compared. Before and after treatment， the traditional Chinese medicine syndrome scores and serum levels of interleukin-6 （IL-6） and tumor necrosis factor- α （TNF- α） were compared between the two groups. The expression levels of vascular endothelial growth factor（VEGF） and fibroblast growth factor 2（FGF2） were compared between the two groups. Western Blot detected the protein expression levels of Rho-associat protein kinase A（RhoA）， Rho-associated coiled-coil protein kinase（ROCK） 1， and ROCK2. Results： The total effective rate in the observation group was 92.50% （37/40）， which was higher than that of 72.50% （29/40） in the control group （P＜0.05）. After treatment，the scores for hematochezia，short and dark urine，and sagging distension of the anal，as well as the serum levels of IL-6 and TNF-α，were significantly decreased in both groups compared to those before treatment （P＜0.05）. The scores for hematochezia， short and dark urine， and sagging distension of the anal，and the serum levels of IL-6 and TNF-α in the observation group were lower than those in the control group （P＜ 0.05）. The expression levels of VEGF and FGF2，and the protein expression levels of RhoA，ROCK1，and ROCK2 in the internal hemorrhoid tissues were lower in the observation group than in the control group （P＜0.05）. Conclusion： GUO's Bianxue Prescription can effectively alleviate the clinical symptoms of patients with internal hemorrhoids with hematochezia of damp-heat pouring downward type，reduce inflammatory responses，and improve clinical effects.