Abstract： Objective： To explore the prescriptions and medicinal usage patterns of LI Dongyuan in treating dyspepsia based on data mining techniques. Methods：Prescriptions for treating dyspepsia from the Li Dong Yuan Yi Xue Quan Shu （Complete Medical Works of LI Dongyuan） were collected and screened to establish a database using Microsoft Excel. The names，four properties，five flavors，and meridian entries of the medicinals in these prescriptions were systematically analyzed for frequency using Microsoft Excel 2020. The associations among the medicinals were further analyzed using SPSS Modeler 18.0， and cluster analysis was performed on high frequency medicinals using SPSS23.0. Results：A total of 51 prescriptions involving 78 different medicinals were included in this study. The top 10 most frequently-used medicinals were Citri Reticulatae Pericarpium， Aurantii Fructus Immaturus， Glycyrrhizae Radix et Rhizoma， Atractylodis Macrocephalae Rhizoma， Massa Fermentata， Pinelliae Rhizoma， Ginseng Radix et Rhizoma， Zingiberis Rhizoma Recens， Bupleuri Radix， and Aucklandiae Radix. Among the 27 high-frequency medicinals（ frequency ≥ 5 times），the properties were mainly warm，neutral，and cold，with warm medicinals appearing 223 times. The flavors were predominantly acrid， bitter， and sweet， with acrid medicinals appearing 222 times and bitter medicinals 199 times. In terms of therapeutic effects， there were six tonic medicinals， which was the most frequent category，followed by five qi-regulating medicinals. Systematic cluster analysis was performed，grouping the medicinals into seven categories： Notopterygii Rhizoma et Radix， Saposhnikoviae Radix， Bupleuri Radix， and Cimicifugae Rhizoma； Alpiniae Oxyphyllae Fructus， Amomi Fructus， Astragali Radix， Angelicae Sinensis Radix， Alpiniae Katsumadai Semen，Glycyrrhizae Radix et Rhizoma，and Ginseng Radix et Rhizoma；Magnoliae Officinalis Cortex and Atractylodis Rhizoma； Aurantii Fructus Immaturus， Atractylodis Macrocephalae Rhizoma， Scutellariae Radix， and Coptidis Rhizoma； Hordei Fructus Germinatus， Citri Reticulatae Pericarpium Viride， and Massa Fermentata；Alismatis Rhizoma，Poria，Citri Reticulatae Pericarpium，Pinelliae Rhizoma，and Zingiberis Rhizoma Recens； Aucklandiae Radix and Zingiberis Rhizoma. Conclusion： LI Dongyuan's clinical treatment of dyspepsia primarily focused on qi-regulating medicinals，with the most frequent use of medicinals targeting the spleen meridian. This reflects his holistic approach to treating dyspepsia， emphasizing the use of acrid medicinals to open and bitter medicinals to promote descent， and highlighting the importance of tonifying the spleen and stomach， as well as promoting qi movement and digestion in the treatment of dyspepsia.