Abstract：Objective：To observe the clinical effects of Suhexiang Pills combined with Edaravone in the treatment of acute cerebral infarction （ACI） and its impact on serum levels of stress-induced protein 2 （Sestrin2）. Methods：A total of 90 ACI patients diagnosed and treated at The Second Affiliated Hospital of Zhejiang Chinese Medical University from June 2021 to October 2023 were divided into the western medicine group and the combination group via a random number table method，with 45 patients in each group. The western medicine group was treated with Edaravone，while the combination group received Suhexiang Pills combined with Edaravone. The course of treatment was two weeks for both groups. Clinical effects，hemorheological indicators ［whole blood high-shear viscosity （HBV），whole blood lowshear viscosity （LBV），plasma viscosity （PV）]，serum inflammatory cytokines [interleukin-6（ IL-6），tumor necrosis factor-α （TNF-α）]，Sestrin2，and National Institutes of Health Stroke Scale （NIHSS） scores were compared between the two groups. Results： After treatment， the total effective rate was 97.78% （44/45） in the combination group and 82.22%（ 37/45） in the western medicine group，the difference being significant（ P＜0.05）. The levels of HBV，LBV， and PV were reduced in both groups when compared with those before treatment （P＜0.05）， and the levels of these three indicators were lower in the combination group than in the western medicine group （P＜0.05）. The levels of IL-6 and TNF-α were also reduced in both groups when compared with those before treatment （P＜0.05），and the levels of these two indicators were lower in the combination group than in the western medicine group （P＜0.05）. The levels of Sestrin2 were decreased in both groups when compared with those before treatment （P＜0.05），and the level of Sestrin2 was lower in the combination group than in the western medicine group （P＜0.05）. The NIHSS scores were reduced in both groups when compared with those before treatment （P＜0.05），and the NIHSS score was lower in the combination group than in the western medicine group （P＜0.05）. Conclusion： The therapy of Suhexiang Pills combined with Edaravone can effectively improve the hemorheological status and neurological deficit symptoms in ACI patients，reduce inflammation and stress responses，and enhance clinical effects.