Abstract： Objective： To observe the effect of Ditan Prescription combined with bloodletting therapy along channel and jing-well point on postoperative awakening effect，cerebral vascular dynamics，and serum fibrinogen-like protein 2 （FGL2） and B-cell lymphoma-2 （Bcl-2） levels in hypertensive cerebral hemorrhage patients. Methods：A total of 90 cases of patients with hypertensive cerebral hemorrhage treated at Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University from January 2022 to January 2024 were randomly divided into the control group and the study group， with 45 cases in each group， using a random number table method. Both groups received basic treatment， while the control group was treated with bloodletting therapy along channel and jing-well point. The study group received treatment with both the control group and the Ditan Prescription. Compared the clinical efficacy and recovery time in the two groups， as well as the National Institutes of Health Stroke Scale （NIHSS）， Glasgow Coma Scale （GCS） scores， cerebral edema index， and cerebral vascular dynamics indicators （peripheral resistance，mean blood flow，critical pressure） of the affected cerebral artery before and after treatment. Measured the cluster of differentiation 163 （CD163）， tumor necrosis factor- α （TNF-α）， Bcl-2， brain-derived neurotrophic factor（ BDNF），anti-β2 glycoprotein 1 antibody（ a β 2GP1），and FGL2 levels in serum. Results：The total effective rate was 97.78% （44/45） in the study group， and 82.22% （37/45） in the control group， the difference being significant （P＜0.05）. After treatment， the NIHSS scores in both groups were decreased when compared with those before treatment （P＜0.05）， and the NIHSS score in the study group was lower than that in the control group （P＜ 0.05）；the GCS scores in both groups were increased when compared with those before treatment （P＜0.05），and the GCS score in the study group was higher than that in the control group （P＜0.05）. After treatment，the average recovery time in the study group was shorter than that in the control group，and the difference was significant （P＜0.05）. After treatment，the cerebral edema indexes in both groups were decreased when compared with those before treatment （P＜ 0.05）， and the cerebral edema index in the study group was lower than that in the control group （P＜0.05）. After treatment， the peripheral resistance and critical pressure of cerebral arteries in both groups were decreased when compared with those before treatment （P＜0.05），and the peripheral resistance and critical pressure of cerebral arteries in the study group were lower than those in the control group （P＜0.05）；the average blood flow of cerebral arteries in both groups were increased when compared with those before treatment （P＜0.05）， and the average blood flow of cerebral arteries in the study group was higher than that in the control group （P＜0.05）. After treatment，the levels of CD163，TNF-α，and a β 2GP1 in both groups decreased compared to before treatment （P＜0.05），and the levels of CD163， TNF- α， and a β 2GP1 in the study group were lower than those in the control group （P＜0.05）. After treatment，the levels of Bcl-2 and FGL2 in both groups were decreased when compared with those before treatment（ P＜ 0.05），and the levels of Bcl-2 and FGL2 in the study group were lower than those in the control group （P＜0.05）；the levels of BDNF in both groups were increased when compared with those before treatment （P＜0.05），and the level of BDNF in the study group was higher than that in the control group （P＜0.05）. Conclusion：The combination of Ditan Prescription and bloodletting therapy along channel and jing-well point can reduce inflammation response and nerve damage，improve cerebral vascular dynamics，promote cerebral edema resolution，and have a good awakening effect and clinical efficacy in the treatment of hypertensive intracerebral hemorrhage patients.