Abstract： Objective： To observe the clinical effect of Jiakang No. 1 Prescription combined with Thiamazole Tablets on the treatment of Graves' disease （GD） of vigorous heart-liver fire type. Methods：A total of 60 patients with GD treated at the outpatient clinic of Shanghai Huangpu District Hospital of Integrated Chinese and Western Medicine from June 2022 to March 2024 were selected and randomly divided into the treatment group and the control group according to random number table method， with 30 patients in each group. The treatment group received Thiamazole Tablets combined with Jiakang No. 1 Prescription， while the control group received only oral administration of Thiamazole Tablets. After three months of treatment， the changes in traditional Chinese medicine（TCM） syndrome scores， thyroid function indicators [thyroid-stimulating hormone （TSH）， free triiodothyronine （FT3）， free thyroxine （FT4）]，thyroid-stimulating hormone receptor antibody （TRAb） titers，thyroid volume，and exophthalmos degree were compared between the two groups before and after treatment. The effects and safety were also evaluated. Results：After treatment，the total effective rate was 96.67% （29/30） in the treatment group and 93.33% （28/30） in the control group，there being no significant difference between the two groups （P＞0.05）. After treatment，the TCM syndrome scores in both groups were decreased when compared with those before treatment （P＜0.05），and the TCM syndrome scores in the treatment group were lower than those in the control group （P＜0.05）. After treatment， the thyroid volumes of both groups were decreased when compared with those before treatment （P＜0.05），but there was no statistically significant difference in thyroid volume between the two groups （P＞0.05）. After treatment， the FT3 and FT4 levels in both groups were decreased when compared with those before treatment （P＜0.05），while the TSH levels were increased when compared with those before treatment （P＜0.05）. However，there were no statistically significant differences in FT3，FT4，and TSH levels between the two groups （P＞0.05）. After treatment，the TRAb titers of both groups were decreased when compared with those before treatment （P＜0.05）， and the TRAb titers of the treatment group were lower than those of the control group （P＜0.05）. After treatment，the left and right exophthalmos degrees of both groups were improved when compared with those before treatment （P＜0.05）， and the improvement in the treatment group was better than that in the control group （P＜0.05）. The incidence of adverse reactions was 7.14% （2/ 30） in the treatment group and 26.67% （8/30） in the control group， the difference being significant （P＜0.05）. Conclusion：The therapy of Jiakang No.1 Prescription combined with Thiamazole Tablets can better improve the TCM symptoms and thyroid function in patients with GD of vigorous heart-liver fire type， reduce TRAb titers， decrease thyroid volume and exophthalmos degree，and have fewer adverse reactions.