中药足浴联合左旋甲状腺素片治疗肾阳虚型妊娠早期甲状腺功能减退症临床研究
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R714.25

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东阳市科学科技局项目(22-314)


Clinical Study on Chinese Medicine Foot Bath Combined with Levothyroxine Tablets for Early Pregnancy Hypothyroidism of Kidney Yang Deficiency Type
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    摘要:

    目的:观察中药足浴联合左旋甲状腺素片治疗肾阳虚型妊娠早期甲状腺功能减退症的临床疗效。 方法:将东阳市妇幼保健院2023年1—12月诊治的80例肾阳虚型妊娠早期甲状腺功能减退症患者使用随机数 字表法分为对照组和治疗组,每组40例。对照组予以左旋甲状腺素片治疗,治疗组予以中药足浴联合左旋甲 状腺素片治疗。2组均治疗12周。比较2组临床疗效、中医证候积分、甲状腺功能指标[游离三碘甲状腺原氨 酸(FT3)、促甲状腺素(TSH)、游离甲状腺素(FT4)] 及不良妊娠结局。结果:治疗12周后,总有效率治 疗组92.50%(37/40),高于对照组77.50%(31/40),差异有统计学意义(P<0.05)。2组中医证候积分均较治 疗前降低,治疗组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。2组血清FT3、FT4水平均较治 疗前升高,治疗组血清FT3、FT4水平均高于对照组,差异均有统计学意义(P<0.05)。2组血清TSH水平均较 治疗前降低,治疗组血清TSH水平低于对照组,差异均有统计学意义(P<0.05)。随访至妊娠结束,不良妊娠 结局发生率治疗组5.00%(2/40),低于对照组20.00%(8/40),差异有统计学意义(P<0.05)。结论:在左旋 甲状腺素片基础上加用中药足浴治疗肾阳虚型妊娠早期甲状腺功能减退症可起到增效作用,能促进甲状腺功能 恢复,降低不良妊娠结局。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Chinese medicine foot bath combined with Levothyroxine Tablets on early pregnancy hypothyroidism of kidney yang deficiency type. Methods: A total of 80 cases of patients with early pregnancy hypothyroidism of kidney yang deficiency type treated at Dongyang Maternal and Child Health Hospital from January to December 2023 were randomly divided into the control group and the treatment group using a random number table method,with 40 cases in each group. The control group was treated with Levothyroxine Tablets, and the treatment group was treated with Chinese medicine foot bath combined with Levothyroxine Tablets. Both groups were treated for 12 weeks. Compared the clinical efficacy, traditional Chinese medicine(TCM) syndrome scores, thyroid function indicators [free triiodothyronine( FT3),thyroid stimulating hormone( TSH),and free thyroxine( FT4)], and adverse pregnancy outcomes between the two groups. Results:After 12 weeks of treatment,the total effective rate was 92.50% (37/40) in the treatment group,which was higher than that of 77.50% (31/40) in the control group,the difference being significant (P<0.05). The TCM syndrome scores in both groups were decreased when compared with those before treatment,and the TCM syndrome scores in the treatment group were lower than those in the control group, differences being significant (P<0.05). The levels of serum FT3 and FT4 in both groups were increased when compared with those before treatment,and the levels of serum FT3 and FT4 in the treatment group were higher than those in the control group, differences being significant (P<0.05). The serum TSH levels in both groups were decreased when compared with those before treatment,with the treatment group having lower serum TSH level than the control group, differences being significant (P<0.05). During follow-up until the end of pregnancy, the incidence of adverse pregnancy outcomes was 5.00% (2/40) in the treatment group, which was lower than that of 20.00% (8/40) in the control group, the difference being significant (P<0.05). Conclusion: Based on Levothyroxine Tablets, the additional application of Chinese medicine foot bath can enhance the efficacy of treating early pregnancy hypothyroidism of kidney yang deficiency type,promote thyroid function recovery,and reduce adverse pregnancy outcomes.

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王怡萍,史佳丽.中药足浴联合左旋甲状腺素片治疗肾阳虚型妊娠早期甲状腺功能减退症临床研究[J].新中医,2025,57(8):81-85

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  • 在线发布日期: 2025-04-27
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