Abstract： Objective： To observe the clinical effect of modified Maxing Erchen Decoction combined with fire cupping based on the Salmeterol and Fluficasone treatment on chronic persistent bronchial asthma in children with deficiency of both lung and spleen syndrome. Methods：A total of 88 children of chronic persistent bronchial asthma with deficiency of both lung and spleen syndrome who received treatment at Haining Hospital of Chinese Medicine from April 2023 to May 2024 were randomly divided into the control group and the observation group，with 44 cases in each group. Both groups were treated with Salmeterol and Fluficasone，while the observation group was treated with modified Maxing Erchen Decoction combined with fire cupping therapy. Both groups were treated for four weeks. Evaluated traditional Chinese medicine syndrome scores before and after treatment， measured lung function indicators such as forced vital capacity （FVC），forced expiratory volume in one second （FEV1），maximum expiratory flow rate （PEF）， and FEV1/FVC values，inflammatory factor indicators such as eosinophil count，amyloid protein，C-reactive protein， and airway remodeling indicators such as vascular endothelial growth factor， transforming growth factor beta 1， and endothelin 1. Compared the disappearance time of sputum， cough， asthma， wheezing， and the clinical efficacy between the two groups. Results：After treatment，the total effective rate in the observation group was higher than that in the control group （P＜0.05）. The disappearance time of sputum，cough，asthma，and wheezing in the observation group was shorter than that in the control group （P＜0.05）. Both groups showed a decrease in scores of cough and thin phlegm， fatigue and no desire to speak， shortness of breath， sweating， and whitish complexion with lusterless complexion compared to those before treatment （P＜0.05）； the scores of the four traditional Chinese medicine syndromes in the observation group were lower than those in the control group （P＜0.05）. The FVC，FEV1，FEV1/FVC， and PEF values in both groups were increased when compared with those before treatment （P＜0.05），and the values of the four indicators in the observation group were higher than those in the control group （P＜0.05）. The counts of serum eosinophils and the levels of amyloid protein， C-reactive protein， vascular endothelial growth factor， transforming growth factor beta 1，and endothelin 1 in both groups were decreased when compared with those before treatment （P＜ 0.05）；the values of the six indicators in the observation group were lower than those in the control group （P＜0.05）. Conclusion：The combination of modified Maxing Erchen Decoction and fire cupping therapy on the basis of Salmeterol and Fluficasone has good clinical effects in the treatment of chronic persistent bronchial asthma in children with deficiency of both lung and spleen syndrome. It can accelerate the relief of symptoms，reduce inflammatory reactions， improve lung function，and has high safety.