Abstract： Objective： To explore the potential mechanism of Plantaginis Herba in treating psoriasis based on network pharmacology and molecular docking technology. Methods： The active ingredients and target genes of Plantaginis Herba were screened through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP），Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine （TCMIP） and SwissTargetPrediction database. The disease-related target genes of psoriasis were retrieved by using databases of the Disease Gene Network （Disgenet）， GeneCards， Therapeutic Target Database （TTD） and Online Mendelian Inheritance in Man （OMIM）；the intersection of the screened target genes of Plantaginis Herba and the disease-related target genes of psoriasis was taken to obtain the Plantaginis Herba-psoriasis intersection target genes to make the Venn diagram of the drug-disease intersection target genes. Using Cytoscape 3.9.1 software， the gene network diagram of active ingredients of Plantaginis Herba-psoriasis intersection target genes. The protein-protein interaction （PPI） network was constructed in the Search Tool for the Retrieval of Interacting Genes （STRING） database，and Cytoscape 3.9.1 software was used to screen the core targets of the PPI network. The Database for Annotation，Visualization and Integrated Discovery （DAVID） database was used for Gene Ontology （GO） functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes （KEGG） signaling pathway enrichment analysis，and the drug active componentsdisease- targets-pathways network was established. Finally，Autodocktools 1.5.7 software was used to conduct molecular docking verification of the main active ingredients of Plantaginis Herba and the core targets of Plantaginis Herba in treating psoriasis. Results： A total of 400 target genes of active ingredients of Plantaginis Herba， 4 893 diseaserelated target genes of psoriasis，and 186 Plantaginis Herba-psoriasis intersection target genes were identified. The PPI network analysis suggested that targets such as tumor protein 53 （TP53），AKT serine/threonine kinase 1 （AKT1） and mitogen-activated protein kinase 1（ MAPK1） are the core targets of Plantaginis Herba in the treatment of psoriasis. Core targets-Plantaginis Herba active ingredient network map showed that Chlorogenic Acid, Dinatin， Baicalein, and Luteolin may be the key active ingredients of Plantaginis Herba in the treatment of psoriasis. The results of GO functional enrichment analysis showed that Plantaginis Herba may play a role in the treatment of psoriasis by affecting biological processes such as inflammatory responses， positive and negative regulation of the apoptotic process， response to lipopolysaccharide， and protein phosphorylation. The results of KEGG enrichment analysis indicated that signaling pathways such as phosphatidylinositol 3-kinase/protein kinase B （PI3K-AKT）， MAPK and interleukin-17 （IL-17） are important signaling pathways for Plantaginis Herba in treating psoriasis. Molecular docking results showed that the main active ingredients of Plantaginis Herba，including Chlorogenic Acid，Dinatin，Baicalein，and Luteolin，have a higher affinity for core targets TP53， AKT1， MAPK1， heat shock protein 90 alpha family class A member 1 （HSP90AA1）， and tumor necrosis factor （TNF）. Conclusion： The Chlorogenic Acid， Dinatin， Baicalein， and Luteolin in Plantaginis Herba may regulate the signaling pathways of PI3K-AKT，MAPK and IL-17 through multiple targets such as TP53， AKT1， and MAPK1， thereby affecting the physiological processes of inflammatory responses and apoptosis in patients with psoriasis，and playing a role in the treatment of psoriasis.