Abstract： This article introduces Professor LI Shunmin's clinical experience in treating chronic renal failure. Professor LI believes that the fundamental pathogenesis of chronic renal failure is the deficiency of the spleen and kidney， complicated with the interlocking of dampness， turbidity， stasis， and toxins. The spleen and kidney deficiency runs throughout the disease course. Therefore， based on the theory of spleen-kidney correlation and combined with microscopic syndrome differentiation，he developed the Jianpi Yishen Prescription to treat chronic renal failure. In clinical practice， he emphasizes the principle of "two supplements and five unblocks. " The "two supplements" refer to the primary treatment methods of tonifying the spleen and kidneys. The "five unblocks" include promoting bowel movements，urination，sweating，smooth breathing，and blood circulation.