独参汤合五加生化胶囊联合常规西药治疗产后宫缩乏力性出血临床研究
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R714.46

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岱山县科技局科研项目(202107)


Clinical Study on Dushen Decoction and Wujia Shenghua Capsules Combined with Routine Western Medicine for Postpartum Hemorrhage Caused by Uterine Atony
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    摘要:

    目的:观察独参汤合五加生化胶囊联合常规西药治疗产后宫缩乏力性出血的疗效及对子宫复旧状 况的影响。方法:回顾性选取2022年4月—2024年4月于岱山县第一人民医院分娩的85例产后宫缩乏力性出 血产妇的临床资料,根据止血治疗方式不同分为常规治疗组41例和中药治疗组44例。常规治疗组采用宫缩素 联合米索前列醇治疗,中药治疗组在常规治疗组的基础上口服独参汤合五加生化胶囊治疗,2组均治疗7 d。评 价2组临床疗效,比较2组子宫复旧情况及患者治疗前后的凝血因子指标[凝血酶原时间(PT)、活化部分凝 血活酶时间(APTT)、凝血酶时间(TT)]、纤溶功能指标[血小板(BPC)、血红蛋白(Hb)]、中医症候积 分。结果:中药治疗组总有效率为93.18%(41/44),高于常规治疗组70.73%(29/41)(P<0.05)。中药治疗组 恶露持续时间短于常规治疗组,产后72 h出血量、子宫复旧不良率及宫内稍强回声率均低于常规治疗组,差异 均有统计学意义(P<0.05)。治疗后,2组中医证候积分较治疗前降低(P<0.05),且中药治疗组中医证候积 分低于常规治疗组(P<0.05)。治疗后,2组PT、APTT、TT水平较治疗前降低(P<0.05),且中药治疗组PT、 APTT、TT水平低于常规治疗组(P<0.05)。治疗后,2组BPC、Hb水平较治疗前升高(P<0.05),且中药治 疗组BPC、Hb水平高于常规治疗组(P<0.05)。结论:独参汤合五加生化胶囊联合常规西药治疗产后宫缩乏 力性出血的临床疗效较好,能有效缩短阴道出血持续时间,降低出血量,同时改善凝血功能,有助于子宫 的恢复。

    Abstract:

    Abstract: Objective: To observe the curative effect of Dushen Decoction and Wujia Shenghua Capsules combined with routine western medicine on postpartum hemorrhage caused by uterine atony and its impact on uterine involution. Methods: This retrospective study selected clinical data from 85 cases of puerpera with postpartum hemorrhage caused by uterine atony at Daishan First People's Hospital between April 2022 and April 2024. The patients were divided into the routine treatment group (41 cases) and the Chinese medicine treatment group (44 cases) based on the hemostatic treatment method. The routine treatment group was treated with Oxytocin combined with Misoprostol,and the Chinese medicine treatment group was additionally given the oral administration of Dushen Decoction and Wujia Shenghua Capsules based on the treatment of the routine treatment group. Both groups were treated for seven days. Clinical effects were evaluated in the two groups; the coagulation factors [prothrombin time (PT), activated partial thromboplastin time (APTT) , thrombin time (TT)], fibrinolytic function indexes [platelet count (BPC) , hemoglobin (Hb)],and traditional Chinese medicine syndrome scores before and after treatment and uterine involution were compared between the two groups. Results:The total effective rate in the Chinese medicine treatment group was 93.18% (41/44),higher than 70.73% (29/41) in the routine treatment group (P<0.05). The duration of lochia in the Chinese medicine treatment group was shorter than that in the routine treatment group,and the amount of bleeding at 72 hours after delivery, the rate of uterine subinvolution and the rate of slightly hyperechoic intrauterine foci in the uterus were lower than those in the routine treatment group,differences being significant (P<0.05). After treatment, traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment( P<0.05),and the Chinese medicine treatment group had lower scores than the routine treatment group( P< 0.05). After treatment, the PT, APTT, and TT in the two groups were shorter when compared with those before treatment (P<0.05), with the Chinese medicine treatment group showing shorter time than the routine treatment group (P<0.05). After treatment, the levels of BPC and Hb in the two groups were increased when compared with those before treatment (P<0.05), with the Chinese medicine treatment group showing higher levels than the routine treatment group (P<0.05). Conclusion: The combination of Dushen Decoction and Wujia Shenghua Capsules with routine western medicine is effective in treating postpartum hemorrhage caused by uterine atony. It can effectively shorten the duration of vaginal bleeding, reduce the amount of bleeding, improve coagulation function, and aid in uterine recovery.

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单雅娟,王雪红,孙玉敏.独参汤合五加生化胶囊联合常规西药治疗产后宫缩乏力性出血临床研究[J].新中医,2025,57(9):29-33

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  • 在线发布日期: 2025-05-12
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