Abstract： Objective： To observe the curative effect of the combination use of modified Danggui Niantong Decoction and Colchicine Tablets on acute gouty arthritis （AGA） of damp-heat obstruction type and its effect on serum glucose transporter 9 （GLUT9） and urate transporter 1 （URAT1）. Methods：A total of 92 AGA patients of damp-heat obstruction type who were admitted to the outpatient department of Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from January to September 2024 were selected and divided into the treatment group and the control group according to the random number table method，with 46 cases in each group. The control group was treated with Colchicine Tablets，and the treatment group was treated with modified Danggui Niantong Decoction combined with Colchicine Tablets. The clinical effects and the incidence of adverse reactions，and the changes of traditional Chinese medicine syndrome scores，scores of Visual Analogue Scale （VAS） of pain，laboratory indexes [interleukin-1β （IL- 1β）， C-reactive protein （CRP）， erythrocyte sedimentation rate （ESR）， blood uric acid （BUA）， URAT1 and GLUT9] before and after treatment were compared between the two groups. Results：The total clinical effective rate was 78.26% （36/46） in the control group， and 93.48% （43/46） in the treatment group， there being significance in the difference （P＜0.05）. After treatment，the traditional Chinese medicine syndrome scores of joint fever，joint swelling， joint tenderness， joint motion disorder， dry mouth and thirst， vexation， yellow urine， slippery or unevent pulse， yellow and slimy or yellow and thin coating， red or dark purple tongue and the total scores in the two groups were reduced when compared with those before treatment （P＜0.05）. The above 10 traditional Chinese medicine syndrome scores and total scores in the treatment group were lower than those in the control group （P＜0.05）. After treatment，the VAS scores in the two groups were down-regulated when compared with those before treatment （P＜0.05）， and the VAS score in the treatment group was lower than that in the control group （P＜0.05）. The levels of IL-1β，CRP，ESR， BUA， URAT1 and GLUT9 in the two groups were dwindled when compared with those before treatment （P＜0.05）， and the above six levels in the treatment group were higher than those in the control group （P＜0.05）. After treatment， the incidence of adverse reactions was 6.52% （3/46） in the treatment group，and 17.39% （8/46） in the control group， there being no significance in the difference （P＞0.05）. Conclusion： The combination use of modified Danggui Niantong Decoction and Colchicine Tablets has a good curative effect on AGA of damp-heat obstruction type，which can relieve the clinical symptoms， reduce the degree of joint swelling and joint pain， improve the range of joint motion， decrease the degree of joint inflammation and BUA with great safety.