Abstract： Objective： To observe the clinical effect of Ginkgo Biloba Extract combined with Aspirin in the treatment of acute cerebral infarction （ACI）. Methods：A total of 96 patients with ACI admitted to Zhejiang Veteran Hospital from March 2021 to March 2024 were selected and randomly divided into a control group and an observation group by random number table method，each with 48 cases. Both groups received routine symptomatic treatment. The control group was treated with Aspirin Enteric-Coated Tablets on the basis of routine symptomatic treatment，while the observation group was additionally treated with intravenous infusion of Ginkgo Biloba Extract Injection on the basis of the control group. The treatment duration for both groups was 14 days. The clinical efficacy of the two groups was evaluated， and the scores of the National Institutes of Health Stroke Scale （NIHSS） and the modified Rankin Scale （mRS） before and after treatment were compared. Levels of serum lactate dehydrogenase （LDH）， high-sensitivity C-reactive protein （hs-CRP）， serum amyloid A （SAA）， and D-dimer （D-D） were also compared. The occurrence of adverse reactions was observed. Results： The total effective rate in the observation group was 91.67% （44/48）， which was higher than that in the control group 75.00% （36/48） （P＜0.05）. After treatment，the NIHSS and mRS scores in both groups were decreased compared with those before treatment （P＜0.05），and the scores in the observation group were lower than those in the control group （P＜0.05）. After treatment，the levels of serum LDH，hs-CRP，D-D，and SAA in both groups were decreased compared with those before treatment （P＜0.05），and the levels in the observation group were lower than those in the control group （P＜0.05）. No significant adverse reactions were observed in either group. Conclusion： The combination of Ginkgo Biloba Extract and Aspirin can effectively enhance cerebral protection in patients with ACI，reduce the levels of hs-CRP and D-D，promote the recovery of neurological function，with good safety.