清金化痰益肺汤联合布地奈德治疗慢性阻塞性肺疾病稳定期临床研究
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Clinical Study on Qingjin Huatan Yifei Decoction Combined with Budesonide for Chronic Obstructive Pulmonary Disease at Stable Stage
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    摘要:

    目的:观察清金化痰益肺汤联合布地奈德对慢性阻塞性肺疾病(COPD) 稳定期患者胸部CT定量 参数和肺功能的影响。方法:回顾性分析2021年1月—2023年1月安吉县中医医院收治的97例COPD稳定期患 者的临床资料,根据不同的治疗方案分为对照组48例与联合组49例。对照组采用布地奈德混悬液治疗,联合 组在对照组的基础上采用清金化痰益肺汤治疗。比较2 组临床疗效, 比较2 组治疗前后圣乔治呼吸问 卷(SGRQ) 评分、中医证候积分、胸部CT定量参数[肺血管总体积(TBV)、肺血管数量(Ntotal)、横截面积小 于5 mm2 肺小血管数量(NCSA<5)、肺血管面积小于5 mm2 的体积(BV5)] 以及肺功能[第1 秒用力呼气 量(FEV1)、用力肺活量(FVC)、第1秒用力呼气量与用力肺活量比值(FEV1/FVC)]。结果:联合组总有效 率93.88% (46/49),高于对照组79.17% (38/48)(P<0.05)。治疗后,2 组SGRQ 评分、中医证候积分均降 低(P<0.05),且联合组低于对照组(P<0.05)。治疗后,2组TBV、Ntotal、NCSA<5、BV5均降低(P<0.05), 且联合组低于对照组(P<0.05)。治疗后,2组FEV1、FVC、FEV1/FVC水平均升高(P<0.05),且联合组高于 对照组(P<0.05)。结论:清金化痰益肺汤联合布地奈德混悬液治疗能够有效改善胸部CT定量参数和肺功能, 对COPD稳定期患者具有较好的治疗效果。

    Abstract:

    Abstract: Objective: To observe the effects of Qingjin Huatan Yifei Decoction combined with Budesonide on chest CT quantitative parameters and lung function in patients with chronic obstructive pulmonary disease (COPD) at stable stage. Methods:A retrospective analysis was conducted on the clinical data of 97 cases of patients with COPD at stable stage who were admitted to Anji County Hospital of Chinese Medicine from January 2021 to January 2023. According to different treatment regimens, the patients were divided into the control group (48 cases) and the combination group (49 cases). The control group was treated with Budesonide Suspension for Inhalation, and the combination group was additionally treated with Qingjin Huatan Yifei Decoction based on the treatment of the control group. Clinical effects were compared between the two groups;St. George's Respiratory Questionnaire (SGRQ) scores, traditional Chinese medicine syndrome scores, chest CT quantitative parameters [total blood vessel volume of pulmonary (TBV),total number of pulmonary blood vessels (Ntotal),number of small pulmonary blood vessels with a cross-sectional area less than 5 mm2 (NCSA<5),volume of pulmonary blood vessels with an area less than 5 mm2(BV5)], and lung function [forced expiratory volume in the first second (FEV1),forced vital capacity (FVC),and the ratio of FEV1 to FVC (FEV1/FVC)] were compared between the two groups before and after treatment. Results: The total effective rate in the combination group was 93.88% (46/49),higher than 79.17% (38/48) in the control group (P< 0.05). After treatment, SGRQ scores and traditional Chinese medicine syndrome scores were decreased in both groups( P<0.05),with the combination group showing lower scores than the control group( P<0.05). After treatment, the values of TBV,Ntotal,NCSA<5,and BV5 in the two groups were reduced (P<0.05),with the combination group showing lower values than the control group (P<0.05). After treatment,the levels of FEV1,FVC,and FEV1/FVC in the two groups were increased( P<0.05),with the combination group showing higher levels than the control group( P< 0.05). Conclusion: Qingjin Huatan Yifei Decoction combined with Budesonide Suspension for Inhalation can effectively improve chest CT quantitative parameters and lung function,providing a good therapeutic effect for patients with COPD at stable stage.

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沈菊花,刘志富.清金化痰益肺汤联合布地奈德治疗慢性阻塞性肺疾病稳定期临床研究[J].新中医,2025,57(9):56-60

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  • 在线发布日期: 2025-05-12
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