补肾活血汤联合低分子肝素钠治疗复发性流产临床研究
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R714.21

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河南省医学教育研究项目(Wjlz2020126)


Clinical Study on Bushen Huoxue Decoction Combined with Low-Molecular-Weight Heparin Sodium for Recurrent Spontaneous Abortion
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    摘要:

    目的:观察自拟补肾活血汤联合低分子肝素钠治疗肾虚血瘀型复发性流产(RSA) 的临床疗效。 方法:选取2021年1月—2023年12月平顶山市妇幼保健院收治的84例肾虚血瘀型RSA患者,按随机数字表法 分为对照组与观察组各42例。观察期间对照组剔除4例、观察组剔除2例,最终对照组共38例、观察组共 40例完成研究。2组均给予常规保胎处理,对照组加用低分子肝素钠治疗,观察组在对照组基础上给予补肾活 血汤治疗,2组均治疗至孕28周。比较2组临床疗效和妊娠结局,治疗前后中医证候积分、雌激素水平、凝血 指标、子宫动脉阻力学血流参数。结果:观察组总有效率为95.00% (38/40),高于对照组76.32% (29/ 38)(P<0.05)。治疗后,2组主症、次症评分及中医证候积分均低于治疗前(P<0.05),且观察组主症、次症 评分及中医证候积分均低于对照组(P<0.05);2组血清孕酮(P)、β-人绒毛膜促性腺激素(β-HCG)、雌二 醇(E2) 水平均较治疗前升高(P<0.05),且观察组血清P、β-HCG、E2水平均高于对照组(P<0.05);2组 血清D-二聚体(D-D)、纤溶酶原激活物抑制物-1(PAI-1)、纤维蛋白原(Fib) 水平均较治疗前降低(P< 0.05),且观察组血清D-D、PAI-1、Fib水平均低于对照组(P<0.05);2组活化部分凝血活酶时间(APTT) 均 治疗前延长(P<0.05),且观察组APTT长于对照组(P<0.05);2组子宫动脉搏动指数(PI)、阻力指数(RI) 及子宫动脉收缩末期峰值/舒张末期峰值(S/D) 均较治疗前降低(P<0.05),且观察组PI、RI水平及S/D值均 低于对照组(P<0.05)。观察组保胎成功率为87.50% (38/40),高于对照组68.42% (29/38)(P<0.05)。结 论:补肾活血汤联合低分子肝素钠治疗肾虚血瘀型RSA疗效好,可有效缓解症状,改善雌激素水平和凝血功 能,改善子宫动脉阻力,提高保胎成功率。

    Abstract:

    Abstract:Objective:To observe the clinical effect of self-formulated Bushen Huoxue Decoction combined with low-molecular-weight heparin sodium in treating recurrent spontaneous abortion (RSA)with kidney deficiency and blood stasis type. Methods: A total of 84 patients with RSA with kidney deficiency and blood stasis type treated at Pingdingshan Maternal and Child Health Care Hospital from January 2021 to December 2023 were selected and randomly divided into a control group and an observation group by random number table method, with 42 cases in each group. During the study, four cases from the control group and two from the observation group were excluded, leaving 38 cases in the control group and 40 cases in the observation group to complete the study. Both groups received conventional fetal preservation treatment. The control group was treated with low-molecular-weight heparin sodium, while the observation group received additional treatment with Bushen Huoxue Decoction. Treatment continued until the 28th week of pregnancy. Clinical effects,pregnancy outcomes,and the changes in traditional Chinese medicine(TCM) syndrome scores, estrogen levels, coagulation indicators, and uterine artery resistance parameters before and after treatment were compared between the two groups. Results: The total effective rate in the observation group was 95.00% (38/40), higher than that in the control group at 76.32% (29/38) (P<0.05). After treatment, both groups showed significant decreases in the main syndrome scores and the secondary syndrome scores and TCM syndrome scores (P<0.05), with the observation group achieving lower scores than the control group (P<0.05). Serum progesterone (P), β-human chorionic gonadotropin (β-HCG), and estradiol (E2) levels were increased in both groups after treatment (P<0.05),with the observation group showing higher levels than the control group (P<0.05). Serum D-dimer (D-D),plasminogen activator inhibitor-1 (PAI-1),and fibrinogen (Fib) levels were decreased in both groups (P<0.05), with the observation group having lower levels than the control group (P<0.05). Activated partial thromboplastin time (APTT) was prolonged in both groups after treatment (P<0.05), with the observation group showing a longer APTT than the control group (P<0.05). Uterine artery pulsatility index (PI), resistance index (RI),and systolic/diastolic ratio (S/D) were decreased in both groups (P<0.05),with the observation group achieving lower PI, RI, and S/D values than the control group (P<0.05). The fetal preservation success rate was 87.50% (38/40) in the observation group,higher than 68.42% (29/38) in the control group (P<0.05). Conclusion: Bushen Huoxue Decoction combined with low-molecular-weight heparin sodium is effective in treating RSA of kidney deficiency and blood stasis type. It can alleviate symptoms,improve estrogen levels and coagulation function,reduce uterine artery resistance,and increase the success rate of fetal preservation.

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张丹丹,于喜乐.补肾活血汤联合低分子肝素钠治疗复发性流产临床研究[J].新中医,2025,57(9):83-88

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  • 在线发布日期: 2025-05-12
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