补肾养巢膏加针刺疗法联合雌孕激素治疗肾虚型卵巢储备功能减退合并复发性流产临床研究
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R271.9

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温州市科研项目(ZY2022014,Y20240912)


Clinical Study on Bushen Yangchao Soft Extract and Acupuncture Therapy Combined with Estrogen and Progesterone for Diminished Ovarian Reserve Complicated with Recurrent Spontaneous Abortion of Kidney Deficiency Type
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    摘要:

    目的:观察补肾养巢膏加针刺疗法联合雌孕激素治疗肾虚型卵巢储备功能减退(DOR) 合并复发 性流产(RSA) 的临床疗效及对妊娠结局和卵巢功能的影响。方法:选取2022年7月—2023年6月在浙江中医 药大学附属温州市中医院治疗的100例肾虚型DOR合并RSA患者,按随机数字表法分成对照组与试验组各 50例。对照组予雌孕激素治疗,试验组在对照组基础上加用补肾养巢膏联合针刺疗法治疗。3个月经周期为 1个疗程,若第1个疗程结束后未受孕成功,1个月后开始第2个疗程,治疗至受孕成功或达2个疗程。比较 2 组临床疗效、妊娠结局(临床妊娠率、持续妊娠率、活产率) 以及治疗前后卵巢功能[促卵泡生成 素(FSH)、抗苗勒管激素(AMH)]、中医证候积分。结果:治疗后,试验组总有效率90.00%(45/50),高于 对照组72.00%(36/50)(P<0.05)。试验组临床妊娠率、持续妊娠率、活产率均高于对照组(P<0.05)。2组 AMH水平均较治疗前升高(P<0.05),试验组AMH水平高于对照组(P<0.05)。2组FSH水平均较治疗前降 低(P<0.05),试验组FSH水平低于对照组(P<0.05)。2组中医证候积分均较治疗前降低(P<0.05),试验 组中医证候积分低于对照组(P<0.05)。结论:补肾养巢膏加针刺疗法联合雌孕激素治疗肾虚型DOR合并 RSA疗效较好,可缓解临床症状,改善卵巢功能,提高临床妊娠率、持续妊娠率及活产率,安全性好。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Bushen Yangchao Soft Extract and acupuncture therapy combined with estrogen and progesterone treatment on diminished ovarian reserve (DOR) complicated with recurrent spontaneous abortion (RSA) of kidney deficiency type , and its effects on pregnancy outcomes and ovarian function. Methods: A total of 100 cases of patients with DOR complicated with RSA of kidney deficiency type treated at Wenzhou TCM Hospital of Zhejiang Chinese Medical University from July 2022 to June 2023 were selected. They were divided into the control group and the trial group accoring to the random number table method,with 50 cases in each group. The control group received estrogen and progesterone treatment,and the trial group was additionally treated with Bushen Yangchao Soft Extract combined with acupuncture therapy in addition to the control group's treatment. One treatment course consisted of three menstrual cycles. If pregnancy was not achieved after the first course, the second course began one month later, continuing until pregnancy was achieved or up to two courses. Clinical effects and pregnancy outcomes (clinical pregnancy rate,ongoing pregnancy rate,live birth rate) were compared between the two groups. Before and after treatment, ovarian function [follicle-stimulating hormone (FSH) and anti-müllerian hormone (AMH)] and traditional Chinese medicine syndrome scores were compared between the two groups. Results: After treatment, the total effective rate in the trial group was 90.00% (45/50), higher than 72.00% (36/50) in the control group( P<0.05). Clinical pregnancy rates,ongoing pregnancy rates,and live birth rates in the trial group were higher than those in the control group (P<0.05). AMH levels in the two groups were increased when compared with those before treatment (P<0.05),with higher level in the trial group than in the control group (P<0.05). FSH levels in the two groups were decreased when compared with those before treatment (P<0.05),with lower level in the trial group than in the control group (P<0.05). Traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment (P<0.05),with lower score in the trial group than in the control group (P<0.05). Conclusion: Bushen Yangchao Soft Extract combined with acupuncture therapy and estrogen and progesterone treatment has a good curative effect in treating DOR complicated with RSA of kidney deficiency type. It can alleviate clinical symptoms,improve ovarian function,and increase clinical pregnancy rate,ongoing pregnancy rate, and live birth rate,with good safety.

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李爽爽,孙云.补肾养巢膏加针刺疗法联合雌孕激素治疗肾虚型卵巢储备功能减退合并复发性流产临床研究[J].新中医,2025,57(9):89-93

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  • 在线发布日期: 2025-05-12
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