Abstract：Objective：To observe the curative effect of the combination use of acupuncture and western medicine on insomnia in remission stage of bipolar disorder （BD）. Methods：A total of 150 patients with insomnia in remission stage of BD admitted to the Third Hospital of Quzhou from January 2022 to December 2024 were selected as the study subjects and divided into the control group and the study group according to the random number table method， with 75 cases in each group. The control group was treated with western medicine， and the study group was additionally treated with acupuncture based on the treatment in the control group. After eight weeks of treatment，the clinical effects， and the changes of scores of Pittsburgh Sleep Quality Index （PSQI）， Bech-Rafaelsen Mania Rating Scale （BRMS）， Self-Rating Depression Scale（ SDS） and Self-Rating Anxiety scale（ SAS），and the levels of polysomnography parameters， serum 5-hydroxytryptamine （5-HT）， melatonin （MT）， β-endorphin （β-EP） and γ-aminobutyric acid （GABA） before and after treatment were compared between the two groups. Results： The total clinical effective rate was 92.00% （69/75） in the study group and 73.33% （55/75） in the control group， the difference being significant （P＜ 0.05）. After eight weeks of treatment，the scores of PSQI，BRMS，SDS and SAS in the two groups were dwindled when compared with those before treatment （P＜0.05），and the above four scores in the study group were lower than those in the control group （P＜0.05）. After eight weeks of treatment， the total sleep duration and sleep efficiency in the two groups were elevated when compared with those before treatment （P＜0.05），and the sleep latency and wake-up times were reduced when compared with those before treatment （P＜0.05）；the total sleep duration and sleep efficiency in the study group were higher than those in the control group （P＜0.05），and the sleep latency and wake-up times were less than those in the control group （P＜0.05）. After eight weeks of treatment，the levels of serum 5-HT，MT，β-EP and GABA in the two groups were up-elevated when compared with those before treatment （P＜0.05），and the above four levels in the study group were higher than those in the control group （P＜0.05）. Conclusion：The combination use of acupuncture and western medicine has a great curative effect on insomnia in remission stage of BD，which can regulate the level of neurotransmitter secretion，relieve the clinical symptoms and improve the sleep quality.