Abstract：Objective：To analyze the medication rules of ZENG Yonglei in the treatment of post-operative lung cancer based on data mining. Methods： Medical records of post-operative lung cancer patients treated by ZENG Yonglei from January 2021 to June 2024 were collected. The Chinese herbal prescriptions were analyzed for frequency， four natures， five flavors， channel entry， and effects via the Ancient and Modern Medical Records Cloud Platform V2.3.5. Additionally， association analysis， cluster analysis， and complex network analysis of Chinese herbs were conducted. Results：After screening，179 medical records were collected，involving 159 Chinese herbs with a total of 3 236 times of use. High-frequency herbs included Fritillariae Thunbergii Bulbus，Astragali Radix，Citri Reticulatae Pericarpium， Armeniacae Semen Amarum， and Houttuyniae Herba. The main natures were neutral， warm， cold， mild cold， and mild warm； the main flavors were sweet， bitter， and acrid； the main channel entries were lung， spleen，liver，and heart. The main effects included clearing heat，resolving toxins and dissipating masses，moistening the intestines to promote defecation and promote urination，drying dampness，dissolving phlegm and relieving cough， and supplementing qi， nourishing blood and boosting yin. Core herbal pairs included Armeniacae Semen Amarum- Fritilariae Thunbergii Bulbus， Pseudostellariae Radix-Astragali Radix， and Pinelliae Rhizoma Praeparatum Cum Zingibere et Alumine-Citri Reticulatae Pericarpium. Cluster analysis grouped the top 37 high-frequency herbs into 7 categories. The core prescription identified through complex network analysis contained 14 herbs. Conclusion： ZENG Yonglei treatment of post-operative lung cancer patients focuses on reinforcing healthy qi and supplementing deficiency as the fundamental root，while clearing heat and resolving toxins，dissolving phlegm and removing stasis are the branch. Attention is also paid on appetite and sleep，urination and bowel functions，with minimal use of stimulating and aggressive herbs. The prescriptions are concise with moderate dosages.