Abstract： Objective： To analyze the medication rules of Professor HONG Minli in treating stable chronic obstructive pulmonary disease （COPD） by syndrome differentiation based on data mining. Methods：Professor HONG Minli´s Chinese medicine prescriptions for patients with stable COPD from July 2019 to June 2024 were collected and the prescription information was standardized and entered into the Traditional Chinese Medicine Inheritance Support System （V3.5） to establish a database. The modules of statistical analysis and prescription analysis in the system were used to analyze the use frequency， four qi， five flavors and meridian entries of Chinese medicinals. The core combinations of Chinese medicinals were given the association rules analysis， and the core combination prescriptions were extracted by the clustering analysis. Results：A total of 548 prescriptions were included，involving 193 Chinese medicinals. The top 10 Chinese medicinals were Poria， Glycyrrhizae Radix et Rhizoma， Pinelliae Rhizoma， Atractylodis Macrocephalae Rhizoma， Citri Reticulatae Pericarpium， Codonopsis Radix， Jujubae Fructus， Cinnamomi Ramulus， Astragali Radix and Scutellariae Radix. The nature of Chinese medicinals were mainly warm， neutral and cold； the flavors were mainly sweet， bitter and pungent； the meridian entries were mainly the spleen， lung， stomach， heart， kidney and liver. The association rule analysis showed that the top five core medicinal combinations ranked by support were Glycyrrhizae Radix et Rhizoma-Pinelliae Rhizoma， Glycyrrhizae Radix et Rhizoma-Poria， Glycyrrhizae Radix et Rhizoma-Atractylodis Macrocephalae Rhizoma， Poria-Atractylodis Macrocephalae Rhizoma，and Glycyrrhizae Radix et Rhizoma-Poria-Atractylodis Macrocephalae Rhizoma. The top four in confidence levels were “Glycyrrhizae Radix et Rhizoma， Citri Reticulatae Pericarpium→Poria”“Poria， Citri Reticulatae Pericarpium→Glycyrrhizae Radix et Rhizoma”“Pinelliae Rhizoma， Citri Reticulatae Pericarpium→ Glycyrrhizae Radix et Rhizoma” and “Glycyrrhizae Radix et Rhizoma， Citri Reticulatae Pericarpium→Pinelliae Rhizoma”. The network topology showed that the main core medicinals were Cinnamomi Ramulus，Pinelliae Rhizoma， Poria， Citri Reticulatae Pericarpium， Glycyrrhizae Radix et Rhizoma， Atractylodis Macrocephalae Rhizoma， and Jujubae Fructus. K-means cluster analysis showed six core prescriptions，including modified Linggui Zhugan Decoction combined with Liujunzi Decoction， modified Liujunzi Decoction， modified Linggan Wuwei Jiangxin Decoction combined with Banxia Xiexin Decoction， modified Liuwei Dihuang Pills， modified Chaihu associated Decoction and modified Jinshui Liujun Decoction. Conclusion： Professor HONG Minli mainly treats patients with stable COPD by Chinese medicinals for tonifying deficiency， dealing with both the root and branch of the disease， using methods of attack and supplement，and using both cold and warm medicinals.