柴胡疏肝散合生脉散加减治疗阴虚气滞型功能性室性早搏合并焦虑临床研究
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R541.7;R749.7+2

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2023年东莞市社会发展重点项目(20231800900771)


Clinical Study on Treatment of Functional Ventricular Premature Beats Complicated with Anxiety of Yin Deficiency and Qi Stagnation Type with Modified Chaihu Shugan Powder Combined with Shengmai Powder
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    摘要:

    目的:观察在常规西药基础上加用柴胡疏肝散合生脉散加减治疗阴虚气滞型功能性室性早搏合并 焦虑的临床疗效。方法:选取2022年12月—2024年2月在广州中医药大学东莞医院治疗的74例阴虚气滞型功 能性室性早搏合并焦虑患者,使用随机数字表法分为试验组与对照组,每组37例。对照组予琥珀酸美托洛尔 缓释片口服治疗,试验组在对照组基础上加用柴胡疏肝散合生脉散加减口服治疗。2 组均治疗4 周。观察 2组治疗前后24 h动态心电图(早搏次数、平均心率)、中医证候积分、焦虑自评量表(SAS) 评分的变化情 况,评价2组动态心电图疗效及中医证候疗效。结果:治疗4周后,2组早搏次数均较治疗前减少(P<0.05), 试验组早搏次数减少幅度大于对照组(P<0.05)。2组平均心率均较治疗前降低(P<0.05);组间比较,差异 无统计学意义(P>0.05)。2组中医证候总分、SAS评分均较治疗前降低(P<0.05),试验组中医证候总分、 SAS评分降低幅度均大于对照组(P<0.05)。试验组动态心电图疗效及中医证候疗效均优于对照组(P<0.05)。 结论:在常规西药基础上加用柴胡疏肝散合生脉散加减治疗阴虚气滞型功能性室性早搏合并焦虑可以提高临床 疗效,有效减少早搏次数、改善中医证候、缓解焦虑状态。

    Abstract:

    Abstract:Objective:To observe the clinical effect of modified Chaihu Shugan Powder combined with Shengmai Powder on the basis of conventional western medicine in the treatment of functional ventricular premature beats complicated with anxiety of yin deficiency and qi stagnation type. Methods: A total of 74 patients with functional ventricular premature beats complicated with anxiety of yin deficiency and qi stagnation type who were treated at Dongguan Hospital of Guangzhou University of Chinese Medicine from December 2022 to February 2024 were selected and divided into the trial group and the control group via a random number table method,with 37 patients in each group. The control group was treated with oral Metoprolol Succinate Sustained-Release Tablets, while the trial group was additionally treated with oral modified Chaihu Shugan Powder combined with Shengmai Powder on the basis of the control group. Both groups were treated for four weeks. Changes in 24-hour ambulatory electrocardiogram( ECG)(premature beat count, average heart rate), traditional Chinese medicine(TCM) syndrome scores, and Self-Rating Anxiety Scale (SAS) scores before and after treatment were observed, and the effects of ECG and TCM syndromes in both groups were evaluated. Results:After four weeks of treatment,the premature beat count in both groups was decreased when compared with that before treatment (P<0.05),and the decrease in the trial group was greater than that in the control group (P<0.05). The average heart rate in both groups was decreased when compared with that before treatment (P<0.05),there being no significant difference between the two groups (P>0.05). The total scores of TCM syndromes and SAS scores in both groups were decreased when compared with those before treatment (P<0.05),and the decreases in the trial group were greater than those in the control group (P<0.05). The effects of ECG and TCM syndromes in the trial group were better than those in the control group (P<0.05). Conclusion: The addition of modified Chaihu Shugan Powder combined with Shengmai Powder on the basis of conventional western medicine for the treatment of functional ventricular premature beats complicated with anxiety of yin deficiency and qi stagnation type can improve clinical effect, effectively reduce the count of premature beats, improve TCM syndromes, and alleviate anxiety.

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胡苗,侯炽均.柴胡疏肝散合生脉散加减治疗阴虚气滞型功能性室性早搏合并焦虑临床研究[J].新中医,2025,57(10):33-38

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  • 在线发布日期: 2025-05-27
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