Abstract： Objective： To observe the curative effect of the combination use of Huashi Hewei Decoction and quadruple therapy on epigastric pain of damp-heat stagnation type. Method：A total of 108 patients with epigastric pain of damp-heat stagnation type admitted to Kaifeng Central Hospital from May 2020 to June 2023 were selected as the study subjects and divided into the observation group and the control group according to the random number table method， with 54 cases in each group. The two groups were treated with conventional quadruple therapy， and the observation group was additionally treated with Huashi Hewei Decoction at the same time. The course of treatment of both groups was two weeks. Before and after treatment， the traditional Chinese medicine syndrome scores were evaluated， the gastrointestinal motility function indexes [gastrin（ GAS） and motilin（ MOT）] were detected，and the clinical effects， incidence of adverse reactions， eradication rates of helicobacter pylori （Hp） and recurrence rates during 6-month follow-up were compared between the two groups. Results：After treatment，the total effective rate in the observation group was higher than that in the control group （P＜0.05）. The scores of epigastric pain， epigastric oppression and burning，dementia and nausea，and dry mouth and bitter taste in both groups were reduced when compared with those before treatment （P＜0.05）， and the above four scores in the observation group were lower than those in the control group （P＜0.05）. The levels of GAS and MOT in both groups were elevated when compared with those before treatment （P＜0.05），and the levels of GAS and MOT in the observation group were higher than those in the control group（ P＜0.05）. There were no significant differences being found in the comparisons of incidence of adverse reactions， Hp eradication rate， and recurrence rate between the two groups （P＞0.05）. Conclusion： The combination use of Huashi Hewei Decoction and quadruple therapy can improve the curative effect on patients with epigastric pain of dampheat stagnation type，effectively alleviate the symptoms，enhance the gastrointestinal motility function and reduce the risk of recurrence with great safety.