四味代茶饮辅助治疗2 型糖尿病热盛伤津证临床研究
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R255.4

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湖州市公益性应用研究——医卫一般项目(2021GYB70)


Clinical Study on Siwei Daicha Decoction as Adjuvant Therapy for Type 2 Diabetes Mellitus with Syndrome of Excessive Heat Damaging Fluids
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    摘要:

    目的:观察四味代茶饮辅助治疗2型糖尿病热盛伤津证的临床疗效。方法:选取2022年5月— 2024年4月在湖州市南浔区中医院治疗的70例2型糖尿病热盛伤津证患者为研究对象,使用电脑随机分为观察 组及对照组,每组35例。对照组给予盐酸二甲双胍缓释片治疗,观察组在此基础上辅以四味代茶饮治疗,2组 均治疗8周。比较2组血糖指标[空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbA1c)]、中医 证候(口渴多饮、口舌干燥、尿频量多、烦热多汗) 评分、血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密 度脂蛋白胆固醇(HDL-C) 及低密度脂蛋白胆固醇(LDL-C)]及药物不良反应发生率。结果:治疗后,2组 FBG、P2hBG 及HbA1c 水平均较治疗前降低(P<0.05), 观察组FBG、P2hBG 及HbA1c 水平均低于对照 组(P<0.05)。治疗后,对照组口舌干燥、烦热多汗评分与治疗前比较,差异均无统计学意义(P>0.05),口 渴多饮、尿频量多评分均较治疗前降低(P<0.05);观察组口渴多饮、口舌干燥、尿频量多及烦热多汗评分均 较治疗前降低,且均低于对照组(P<0.05)。治疗后,对照组TC、TG、HDL-C、LDL-C 水平以及观察组 HDL-C、LDL-C水平与同组治疗前比较,差异均无统计学意义(P>0.05);观察组TC、TG水平均较治疗前降 低,且均低于对照组(P<0.05)。药物不良反应发生率观察组13.33%(6/35),对照组11.11%(5/35),2组比 较,差异无统计学意义(P>0.05)。结论:四味代茶饮辅助治疗2型糖尿病热盛伤津证,能够提高降糖效果, 改善中医证候和血脂水平,且安全性良好。

    Abstract:

    Abstract : Objective : To observe the clinical effect of Siwei Daicha Decoction as adjuvant therapy for type 2 diabetes mellitus (T2DM) with syndrome of excessive heat damaging fluids. Methods: Seventy patients diagnosed with T2DM with syndrome of excessive heat damaging fluids at Huzhou Nanxun Hospital of Traditional Chinese Medicine from May 2022 to April 2024 were randomly divided into the observation group and the control group by the computer randomization, with 35 cases in each group. The control group received Metformin Hydrochloride Sustained-Release Tablets,while the observation group received additional Siwei Daicha Decoction based on the treatment of the control group. Both groups were treated for eight weeks. The following indexes were compared between the two groups before and after treatment: blood glucose indexes [fasting blood glucose (FBG), 2-hour postprandial blood glucose (P2hBG), glycated hemoglobin (HbA1c)], traditional Chinese medicine (TCM) syndrome scores (constant thirst and excessive drinking,dry mouth and tongue,frequent urination with large volume,vexation and sweating),lipid indexes [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)], and adverse drug reaction incidence rates. Results: After treatment, the levels of FBG, P2hBG, and HbA1c in both groups were decreased when compared with those before treatment (P<0.05), and the levels of FBG, P2hBG, and HbA1c in the observation group were lower than those in the control group (P<0.05). After treatment,the control group showed no statistically significant differences in the scores of dry mouth and tongue, vexation and sweating when compared with those before treatment (P>0.05), but the scores of constant thirst and excessive drinking, and frequent urination with large volume were decreased when compared with those before treatment (P<0.05);in the observation group,the scores of constant thirst and excessive drinking,dry mouth and tongue,frequent urination with large volume,and vexation and sweating were all reduced when compared with those before treatment and were lower than those in the control group (P<0.05). After treatment,there was no statistically significant difference in the levels of the TC,TG,HDL-C and LDL-C in the control group or in the levels of HDL-C and LDL-C in the observation group when respectively compared with those before treatment (P>0.05). However,the levels of TC and TG in the observation group were decreased when compared with those before treatment and were lower than those in the control group (P<0.05). The incidence of adverse drug reactions was 13.33% (6/35) in the observation group and 11.11% (5/35) in the control group, there being no significant difference between the two groups( P>0.05). Conclusion:The adjunctive use of Siwei Daicha Decoction in the treatment of T2DM with excessive heat damaging fluids syndrome can enhance glycemic control,improve TCM syndrome manifestations and lipid indexes, with excellent safety.

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李升,王斌,胡利江.四味代茶饮辅助治疗2 型糖尿病热盛伤津证临床研究[J].新中医,2025,57(10):44-48

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  • 在线发布日期: 2025-05-27
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