针刺疗法联合放松疗法干预长期过量使用唑吡坦患者减停药效果研究
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R256.23;R277.7

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浙江省中医药科技计划项目(2022ZA128)


Study on the Effect of Acupuncture Combined with Relaxation Therapy in Reducing and Discontinuing Zolpidem in Patients with Long-Term Overuse
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    摘要:

    目的:观察在放松疗法的基础上加用针刺疗法对长期过量使用唑吡坦的单纯性失眠患者在减停药 过程中提高成功率的有效性。方法:纳入2021年12月—2023年9月在杭州市红十字会医院就诊的97例单纯性 失眠患者作为研究对象,随机分为治疗组49例、对照组48例。2组均采用唑吡坦片逐渐减量联合放松疗法干 预,治疗组联合针刺疗法干预。2组疗程均为4周。于治疗前、治疗第14天、治疗第28天评定2组患者的失眠 严重程度指数量表(ISI) 评分。比较2组第一阶段(第1~14天)、第二阶段(第15~28天) 的平均日睡眠总 时长、平均日入睡时间、平均日深度睡眠时间。统计、比较2组的睡眠质量达标率、唑吡坦减量达标率、减停 药成功率及治疗前、治疗第14天、治疗第28天ISI评分≤15分的患者比例。结果:治疗组治疗第14天、第 28 天ISI评分≤15分的患者比例均略低于对照组,差异均无统计学意义(P>0.05)。治疗组第一阶段、第二阶 段的睡眠质量达标率均略高于对照组,差异均无统计学意义(P>0.05)。治疗组第二阶段的唑吡坦减量达标率 高于对照组(P <0.05)。治疗4周,治疗组减停药成功率高于对照组(P<0.05)。治疗期间,2组各时间点的平 均日睡眠总时长、平均日入睡时间、平均日深度睡眠时间分别比较,差异均无统计学意义(P>0.05)。治疗组 的平均日睡眠总时长长于对照组,平均日入睡时间略短于对照组。第一阶段,治疗组的平均日深度睡眠时间较 长;第二阶段,对照组的平均日深度睡眠时间较长。结论:采用针刺疗法联合放松疗法干预长期过量使用唑吡 坦的单纯性失眠患者,可减少减停唑吡坦对睡眠质量的影响,在一定程度上缓解长期服药导致的不良反应及药 物依赖,帮助患者顺利度过减停药期,提高减停药成功率。

    Abstract:

    Abstract:Objective:To observe the effectiveness of acupuncture combined with relaxation therapy in improving the success rate of reducing and discontinuing Zolpidem in patients with simple insomnia who have long-term overused Zolpidem. Methods: A total of 97 patients with simple insomnia treated at Hangzhou Red Cross Hospital from December 2021 to September 2023 were included as study subjects and randomly divided into the treatment group (49 cases) and the control group (48 cases). Both groups received gradual reduction of Zolpidem Tablets combined with relaxation therapy,while the treatment group additionally received acupuncture therapy. The treatment courses for both groups were four weeks. The Insomnia Severity Index (ISI) scores were assessed before treatment,at the day 14 and day 28 of treatment. The average daily total sleep duration,average daily sleep onset time,and average daily deep sleep time were compared between the two groups during the first phase (days 1 to 14) and the second phase (days 15 to 28). The sleep quality compliance rates,Zolpidem dosage reduction and successful dose reduction and discontinuation compliance rates, and the proportion of patients with ISI scores ≤15 at the day 14 and day 28 of treatment were statistically compared. Results: The proportion of patients with ISI scores ≤15 at the day 14 and day 28 of treatment was slightly lower in the treatment group than in the control group, there being no significance in differences (P>0.05). The sleep quality compliance rates in the treatment group during both of the first phase and the second phase were slightly higher than those in the control group,the differences were not statistically significant (P> 0.05). In the second phase, the Zolpidem dosage reduction compliance rate in the treatment group was significantly higher than that in the control group (P<0.05). After four weeks of treatment,the success rate of dose reduction and discontinuation in the treatment group was significantly higher than that in the control group (P<0.05). During the treatment period, there were no significant differences in the average daily total sleep duration, average daily sleep onset time, or average daily deep sleep time between the two groups at any time point (P>0.05). The average daily total sleep duration in the treatment group was longer than that in the control group,and the average daily sleep onset time was slightly shorter. In the first phase,the average daily deep sleep time in the treatment group was longer,while in the second phase, the average daily deep sleep time in the control group was longer. Conclusion: Acupuncture combined with relaxation therapy can alleviate the impact of reducing and discontinuing Zolpidem on sleep quality in patients with simple insomnia who have long-term overused Zolpidem. It can also mitigate adverse reactions and drug dependence caused by long-term medication use to some extent, helping patients successfully navigate the reduction and discontinuation period and improving the success rate of reduction and discontinuation.

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厉银锋,叶雅利,吴荣华,张华,张海啸.针刺疗法联合放松疗法干预长期过量使用唑吡坦患者减停药效果研究[J].新中医,2025,57(10):103-108

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  • 在线发布日期: 2025-05-27
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