Abstract： This article introduces Professor LAO Jinxiong´s clinical experience in treating tumor-related depression using acupuncture based on the original qi-reinforcing and heart-nourishing method. Professor LAO Jinxiong posits that the root pathogenesis of this condition lies in the deficiency of orginal qi in the spleen and kidney，coupled with an imbalance between physical and mental states. The therapeutic principle of reinforcing orginal qi and nourishing the heart is emphasized throughout treatment. Clinically， he adopts diagnostic approaches including orginal qi assessment and location， staged heart regulation， and targeted treatment strategies. The foundational acupuncture prescription comprises Back-shu point， Zhongwan （RN12） point， Tianshu （ST25） point， Zusanli （ST36） point， Mingmen（ DU4） point，and Guanyuan（ RN4） point，combined with Shenmen（ HT7） point，Yintang（ EX-HN3） point， Baihui （DU20） point， and Sishencong （EX-HN1） point. This treatment method synergistically reinforces orginal qi， noiurishes the heart，and harmonizes physical and mental states，achieving favorable clinical outcomes.