Abstract：The way of heaven and earth is that harmony between yin and yang fosters the growth of all things；the way of the human body is that harmony between yin and yang ensures regular sleep；the way of husband and wife is that harmony between yin and yang leads to the birth of children. Conception and sleep are natural processes that follow the laws of nature. However，when these processes are disrupted，it indicates an interruption in the natural order. When insomnia and infertility occur simultaneously， it suggests a common underlying disorder. In clinical practice， the author often encounters cases where insomnia and infertility coexist， with each condition frequently affecting and exacerbating the other. These cases often present with a mixture of deficiency and excess， as well as cold and heat. WANG Hongxian believes that for diseases with complex and lingering pathogenesis，treatment should be based on the principle of "harmony." This involves using "harmony" as the foundation， method， and measure， aiming to achieve "unity. " He often employs the modified Chaigui Decoction for syndrome differentiation and treatment. This article， based on WANG Hongxian´s clinical thinking of "achieving unity through harmony， "discusses the Chinese medicine concept of "harmony and unity，" explores the relationship between "harmony and unity" and sleep and fertility，and corroborates this with modern western medical research on the close relationship between sleep and fertility. A case study is included to demonstrate the effectiveness of this approach， aiming to provide insights for the clinical treatment of comorbid insomnia and infertility.