Abstract： This article introduces HAN Yun´s clinical experience in treating acute respiratory distress syndrome （ARDS） caused by sepsis，based on the principles of addressing phlegm，heat，and deficiency. Professor HAN Yun believes that phlegm，heat，and deficiency are the core pathogenesis of this condition. Phlegm and heat are the main pathological factors in sepsis-induced ARDS，with the interaction of phlegm and heat being a crucial aspect of its development. In clinical practice，treatment focuses on clearing heat，resolving phlegm，and tonifying deficiency. Clearing heat and resolving phlegm aim to eliminate pathogenic factors，while tonifying deficiency to support healthy qi and strengthen the body´s resistance.