Abstract： Objective： To summarize YU Genchu's medication rules by data mining the formulas for treating diseases of six-meridians in Chong Ding Tong Su Shang Han Lun （Revised Popular Guide to ‘Treatise on Cold Damage’）. Methods：Formulas for six-meridian diseases from the Six Meridian Formulas and Herbs section of Chong Ding Tong Su Shang Han Lun were selected as the study subject. A database was established，the statistical analysis on use of frequency，nature，flavors and meridian entries of Chinese medicinals was done，and the association rules and cluster analyses were conducted. Results ： A total of 113 internal herbal formulas were screened， including 40 prescriptions using fresh herbs，involving 217 herbal types（ 15 fresh herbs）. High-frequency herbs（ used ≥10 times） included 21 types. Medicinal properties were primarily warm，cold，and neutral；medicinal flavors were predominantly acrid， bitter， and sweet； herbs mainly entered the spleen， stomach， and lung meridians. The most strongly associated herbal pairs were Glycyrrhizae Radix et Rhizoma-Jujubae Fructus，Rhei Radix et Rhizoma-Aurantii Fructus Immaturus，and Glycyrrhizae Radix et Rhizoma-Zingiberis Rhizoma. Cluster analysis identified six groups of Chinese herbs，corresponding to syndrome differentiation and treatment of six-meridian diseases. Conclusion：YU Genchu's approach to treating six meridian diseases is characterized by diverse therapeutic strategies， gentle and precise medication， a strong emphasis on the spleen and stomach， and exceptional skill in resolving dampness. While he applies the six-meridians theory in medication，he adheres to ancient principles.