Abstract： Objective： To analyze the mechanism of Shixiao Powder in treating peptic ulcer using network pharmacology and molecular docking technology. Methods：Chemical components and targets of Shixiao Powder were retrieved from TCMSP，HERB，and SwissTargetPrediction databases. Peptic ulcer-related targets were collected from DrugBank， GeneCards， and OMIM. Common targets were identified via Venn diagram， and a protein-protein interaction （PPI） network was constructed. KEGG pathway and GO functional enrichment analyses were performed via Metascape. Molecular docking validation was conducted with AutoDockTools. Results：（1） A total of 26 chemical components，459 therapeutic targets，1 005 disease targets，and 127 potential targets were identified. GO and KEGG enrichment analyses revealed 1 831 entries and 182 singaling pathways，involving biological processes such as positive regulation of phosphorus metabolic processes， receptor complexes， and protein kinase activity， as well as MAPK， PI3K-Akt， and TNF signaling pathways. （2） Molecular docking demonstrated strong binding between core components （quercetin，kaempferol，isophorone，tocopheryl quinone and pomolic acid） and key targets （TNF，IL6， AKT1，IL1B，PTGS2）. Conclusion：Shixiao Powder exerts potential therapeutic effects on peptic ulcer by alleviating inflammatory responses through multi-target and multi-pathway mechanisms.