麝香通心滴丸联合替米沙坦治疗气虚血瘀型心力衰竭临床研究
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R259.2

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浙江省医学会临床科研基金项目(2023ZYC-A58)


Clinical Study on Shexiang Tongxin Dropping Pills Combined with Telmisartan for Heart Failure of Qi Deficiency and Blood Stasis Type
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    摘要:

    目的:观察麝香通心滴丸联合替米沙坦治疗气虚血瘀型心力衰竭的临床疗效。方法:选取2022年 1月—2024年1月诸暨市中心医院内科收治的98例心力衰竭气虚血瘀型患者,按随机数字表法分为替米沙坦组 和中药联合组各49例。2组治疗期间均未出现脱落病例,替米沙坦组给予替米沙坦进行治疗,中药联合组给予 麝香通心滴丸联合替米沙坦治疗,2组均治疗12周。比较2组临床疗效,比较2组治疗前后中医证候积分、左 心室射血分数(LVEF)、6 min步行试验(6MWT)、氧合指数(OI) 及血清血乳酸(LAC)、基质金属蛋白酶 -9 (MMP-9)、氨基末端脑钠肽前体(NT-proBNP) 水平的变化。结果:治疗后,中药联合组总有效率为 95.92%(47/49),高于替米沙坦组77.55%(38/49)(P<0.05)。2组中医证候积分均较治疗前降低(P<0.05), 中药联合组中医证候积分低于替米沙坦组(P<0.05)。2组LVEF 均较治疗前升高(P<0.05),中药联合组 LVEF高于替米沙坦组(P<0.05)。2组6MWT均较治疗前延长(P<0.05),中药联合组6MWT长于替米沙坦 组(P<0.05)。2组OI均较治疗前升高(P<0.05),中药联合组OI高于替米沙坦组(P<0.05)。2组LAC水平 均较治疗前降低(P<0.05), 中药联合组LAC 低于替米沙坦组(P<0.05)。2 组血清MMP-9 水平、 NT-proBNP水平均较治疗前降低(P<0.05),中药联合组MMP-9、NT-proBNP均低于替米沙坦组(P<0.05)。 结论:麝香通心滴丸联合替米沙坦治疗气虚血瘀型心力衰竭可提升疗效,改善心功能及呼吸功能,降低血乳酸 水平,改善组织血流灌注及心肌损伤,安全性高。

    Abstract:

    Abstract: Objective: To observe the clinical efficacy of Shexiang Tongxin Dropping Pills combined with Telmisartan in treating heart failure of qi deficiency and blood stasis type. Methods:A total of 98 patients with heart failure of qi deficiency and blood stasis type admitted to the Department of Internal Medicine at Zhuji Central Hospital from January 2022 to January 2024 were selected and divided into the Telmisartan group and the combined traditional Chinese medicine(TCM) group using the random number table method, with 49 cases in each group. No cases dropped out during treatment. The Telmisartan group received Telmisartan alone, while the combined TCM group received Shexiang Tongxin Dropping Pills plus Telmisartan. Both groups were treated for 12 weeks. Clinical efficacy was compared between the two groups, along with changes in TCM syndrome scores, left ventricular ejection fraction (LVEF),6-minute walk test (6MWT),oxygenation index (OI),and serum levels of lactate (LAC),matrix metalloproteinase-9 (MMP-9), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) before and after treatment. Results: After treatment, the total effective rate in the combined TCM group was 95.92% (47/49), significantly higher than 77.55% (38/49) in the Telmisartan group (P<0.05). TCM syndrome scores decreased in both groups compared to pretreatment (P<0.05),with the combined TCM group showing lower scores than the Telmisartan group (P<0.05). LVEF improved in both groups (P<0.05), with the combined TCM group demonstrating higher values than the Telmisartan group (P<0.05). The 6MWT distance increased in both groups (P<0.05), with longer distances achieved in the combined TCM group (P<0.05). OI values increased in both groups (P<0.05),with higher levels in the combined TCM group (P<0.05). Serum LAC levels decreased in both groups (P<0.05), with lower levels in the combined TCM group (P<0.05). MMP-9 and NT-proBNP levels decreased in both groups (P<0.05), with the combined TCM group showing greater reductions (P<0.05). Conclusion: Shexiang Tongxin Dropping Pills combined with Telmisartan can enhance therapeutic efficacy in the treatment of heart failure of qi deficiency and blood stasis type, improve cardiac and respiratory function, reduce blood LAC levels, ameliorate tissue perfusion and myocardial injury,with high safety.

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陈莎帅,傅赵明,孟佩盈,郭奕颖.麝香通心滴丸联合替米沙坦治疗气虚血瘀型心力衰竭临床研究[J].新中医,2025,57(11):64-68

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  • 在线发布日期: 2025-06-13
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