Abstract： This paper focuses on the potential advantages of moxibustion in treating senile osteoporosis （SOP）， using the OPG-RANKL-RANK signaling system as a theoretical entry point to explore its mechanism in regulating bone metabolism balance. Given the high prevalence and disability rates associated with SOP， and the connection between Chinese medicine's theory of "kidney governs bones" and modern molecular biology mechanisms， this study aims to systematically analyze the feasibility of moxibustion in improving bone metabolism imbalance through the regulation of the OPG-RANKL-RANK signaling pathway. The article first elucidates the core regulatory role of the OPG-RANKLRANK signaling system in bone formation and metabolism. It then examines the pathological characteristics of SOP， analyzing the intrinsic link between the imbalance of this signaling pathway and the traditional pathogenesis of "kidney yin and yang imbalance." By highlighting the functions of moxibustion in warming the meridians and unblocking the collaterals and regulating the endocrine system，the paper demonstrates its potential effects on the OPG/RANKL ratio， osteoclast activity， and bone density. Additionally， it summarizes the clinical advantages of moxibustion therapy in terms of safety， analgesic effects， and metabolic regulation. This comprehensive analysis provides a theoretical reference for the integration of tradtional Chinese and western medicine in the prevention and treatment of SOP. The paper also suggests future research directions for standardizing moxibustion operational parameters.