Abstract： Objective： To explore the medication rules of Professor ZHOU Yuhong in treating malignant lymphoma using data mining technology. Methods：Clinical data of malignant lymphoma patients treated at Professor ZHOU Yuhong's expert outpatient clinic of the First Affiliated Hospital of Zhejiang Chinese Medical University from March 19，2018，to February 15，2023，were collected to establish a prescription database. Frequency analysis of the medicinals， analysis of the four natures and five flavors， meridian tropism analysis， association rule analysis， and cluster analysis of core medicinals were conducted. Results： A total of 125 patients and 524 prescriptions were included， involving 220 Chinese medicinals with a total frequency of 9 361 occurrences. Among them， 25 Chinese medicinals appeared more than 100 times， with the top five being Poria， Atractylodis Macrocephalae Rhizoma， Codonopsis Radix，Citri Reticulatae Pericarpium，and Bupleuri Radix. The Chinese medicinals were mostly sweet in flavor， with a neutral nature， and primarily enter the spleen and lung meridians. Association rule analysis identified Codonopsis Radix-Poria as the couplet medicinals with the highest confidence， and Codonopsis Radix-Atractylodis Macrocephalae Rhizoma-Poria as the triplet medicinals with the highest confidence. Cluster analysis yielded four core medicinals combinations， namely Sijunzi Decoction， Biejia Jian Pills， and modified Yupingfeng Decoction. Conclusion： Professor ZHOU Yuhong specializes in treating malignant lymphoma with a unique approach that combines spleen-strengthening herbs， phlegm-resolving herbs， qi-regulating herbs， and blood-invigorating herbs. His frequently used herbs includes Codonopsis Radix，Atractylodis Macrocephalae Rhizoma，and Poria to strengthen the spleen and boost qi. He emphasizes strengthening the body's healthy qi and dispelling pathogen，and simultaneously treating the root and branch，and he also flexibly modifies classical prescriptions.