基于数据挖掘技术分析小儿遗尿证型及中药用药规律
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R272

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国家中医药管理局第六批全国老中医药专家学术经验继承工作(国中医药人教发〔2017〕29号)


Analysis of Syndrome Types and Medication Rules of Chinese Medicine for Pediatric Enuresis Based on Data Mining Technology
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    摘要:

    目的:基于数据挖掘技术分析小儿遗尿的证型及中药用药规律。方法:检索自建库以来至2024年 10月31日收录于中国知网(CNKI)、中国学术期刊数据库(COJ)、中文科技期刊数据库(CSTJ) 中使用中药 治疗小儿遗尿的文献,记录证型和中药方剂中的组成药物,统计药物使用频次和性味归经,对使用频次≥ 20 次的高频药物进行关联规则分析和聚类分析。结果:共纳入文献148篇,涉及38种证型,以肾气不固证、 膀胱虚寒证、脾肺两虚证、脾肾两虚证为主要证型。中药处方152个,涉及中药191味,使用频次≥20次的有 27味,使用频次排名前5的药物为益智仁、桑螵蛸、山药、乌药、石菖蒲。功效排名前3的是补益类、收涩 类、理气类药物。药性排名前3的是温、平、微寒。药味排名前3的是甘、辛、苦。归经排名前3的依次为肾、 脾、肺经。关联规则分析得到具有较强关联性的药物组合6组。聚类分析得到常用药对9个、药物核心组合 4组。结论:小儿遗尿常见肾气不固证、膀胱虚寒证及脾肺两虚证等证型,临床使用中药以温补下元、固摄膀 胱为主,兼以益脾、补肺。

    Abstract:

    Abstract: Objective: To analyze the syndrome types and medication rules of Chinese medicine for pediatric enuresis using data mining technology. Methods: We searched for literature on the treatment of pediatric enuresis with Chinese medicine from the inception of the databases to October 31, 2024, in the China National Knowledge Infrastructure( CNKI),China Online Journals( COJ),and Chinese Science and Technology Journal Database( CSTJ). The syndrome types and the composition of Chinese medicine prescriptions were recorded. The usage frequency and the nature, flavor, and meridian tropism of the medicinals were counted. Association rule analysis and cluster analysis were performed on the high-frequency medicinals with a usage frequency of ≥20 times. Results:A total of 148 articles were included, covering 38 syndrome types, with the main ones being kidney qi insecurity syndrome, bladder deficiency-cold syndrome, spleen-lung deficiency syndrome, and spleen-kidney deficiency syndrome. There were 152 Chinese medicine prescriptions involving 191 different medicinals. A total of 27 medicinals had a usage frequency of ≥20 times,with the top five being Alpiniae Oxyphyllae Fructus,Mantidis Oötheca,Dioscoreae Rhizoma,Linderae Radix, and Acori Tatarinowii Rhizoma. The top three therapeutic categories were tonifying, astringent, and qiregulating medicinals. The top three natures were warm,neutral,and slightly cold. The top three flavors were sweet, pungent, and bitter. The top three meridian tropism were kidney, spleen, and lung. Association rule analysis identified six sets of strongly associated medicinal combinations. Cluster analysis identified nine commonly used medicinal couplets and four core combinations. Conclusion: Common syndrome types in pediatric enuresis include kidney qi insecurity syndrome, bladder deficiency-cold syndrome, and spleen-lung deficiency syndrome. In clinical practice,Chinese medicine focuses on warming and supplementing kidney qi and consolidating the bladder,combined with tonifying the spleen and supplementing the lung.

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陈洋,吕郭淳,瞿菲,程芳,向红.基于数据挖掘技术分析小儿遗尿证型及中药用药规律[J].新中医,2025,57(12):1-6

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  • 在线发布日期: 2025-06-26
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