Abstract: Objective: To observe the clinical effect of array microneedling in treating chronic cough after lung cancer surgery. Methods: A total of 62 patients with chronic cough after lung cancer surgery who were treated at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to December 2023 were selected and divided into a trial group and a control group according to the random number table method, each with 31 cases. The control group received sham acupuncture as a placebo treatment on the basis of conventional Chinese herbal anti-tumor therapy,while the trial group received array microneedling treatment on the same basis. Both groups underwent treatment for four weeks. Clinical efficacy was compared between the two groups, and changes in the following parameters were observed before and after treatment: Leicester Cough Questionnaire-Mainland Chinese version( LCQ-MC) scores,Cough Symptom Score( CSS),Visual Analogue Scale( VAS) scores for cough,and levels of inflammatory factors [tumor necrosis factor- α (TNF-α), interleukin-8 (IL-8), and interleukin-13 (IL-13)]. Results: After treatment, the total effective rate in the trial group was 87.10% (27/31), higher than that in the control group at 67.74% (21/31), with the difference being significant (P<0.05). Both groups showed significant increases in LCQ-MC scores in the physical, psychological, and social domains compared to those before treatment( P<0.05),with the trial group showing more pronounced improvements in these domains and the total LCQMC score compared to the control group (P<0.05). The CSS and VAS scores for cough were decreased significantly in both groups compared to those before treatment (P<0.05), with the trial group having lower scores than the control group (P<0.05). Levels of TNF-α, IL-8, and IL-13 did not show significant differences within or between groups before and after treatment (P>0.05). Conclusion:Array microneedling treatment is effective for chronic cough after lung cancer surgery. The improvement in cough symptoms may not be achieved through the alleviation of inflammatory reactions.