补肾活血方联合宫腔镜下宫腔粘连分离术治疗中重度宫腔粘连临床研究
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R713.4

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河南省医学科技攻关计划项目(LHGJ20190370)


Clinical Study on Bushen Huoxue Prescription Combined with Transcervical Resection of Adhesion for Moderate-to-Severe Intrauterine Adhesions
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    摘要:

    目的:观察补肾活血方联合宫腔镜下宫腔粘连分离术(TCRA) 治疗中重度宫腔粘连的临床疗效。 方法:选取2022年6月—2024年6月开封市中医院收治的106例宫腔粘连患者,按随机数字表法分为联合组和 对照组各53例。2组入院后均行TCRA治疗,对照组术后给予戊酸雌二醇片口服,联合组在对照组基础上加用 补肾活血方治疗,2组均连续治疗3周。评价2组临床疗效,统计2组患者术后出血量、出血持续时间、月经复 潮时间、腹痛持续时间,采用B 超检查子宫内膜厚度、宫腔容积及子宫动脉血流阻力指数(RI)、搏动指 数(PI)。治疗后进行为期3个月的随访,统计2组患者宫腔粘连复发、月经过少、闭经等发生情况。结果:联 合组总有效率为96.23% (51/53), 高于对照组83.02% (44/53)(P<0.05)。联合组术后出血量少于对照 组(P<0.05),出血、腹痛持续时间及月经复潮时间均短于对照组(P<0.05)。治疗后,2组子宫内膜厚度、 宫腔容积较治疗前增大(P<0.05),且联合组子宫内膜厚度、宫腔容积均大于对照组(P<0.05)。治疗后, 2组子宫动脉RI及PI较治疗前下降(P<0.05),且联合组子宫动脉RI及PI低于对照组(P<0.05)。联合组宫 腔粘连复发率、闭经发生率低于对照组(P<0.05),妊娠率高于对照组(P<0.05)。结论:补肾活血方联合 TCRA治疗中重度宫腔粘连具有较好的临床效果,可加快术后恢复,改善宫腔形态及子宫动脉血流动力学,降 低宫腔粘连再复发风险,提高妊娠率。

    Abstract:

    Abstract: Objective: To observe the clinical efficacy of Bushen Huoxue Prescription combined with transcervical resection of adhesion (TCRA) for moderate-to-severe intrauterine adhesions. Methods: A total of 106 intrauterine adhesions patients treated at Kaifeng Hospital of Traditional Chinese Medicine from June 2022 to June 2024 were randomly divided into the combination group and the control group (53 cases each). Both groups underwent TCRA,with the control group receiving Estradiol Valerate Tablets postoperatively and the combination group receiving additional Bushen Huoxue Prescription for three weeks continuously. Evaluated the clinical efficacy in the two groups, and calculated the postoperative bleeding volume, bleeding duration, menstrual recovery time, and abdominal pain duration. Used B-ultrasound to examine endometrial thickness, uterine cavity volume, uterine artery blood flow resistance index (RI),and pulsatility index (PI). After treatment,a three-month follow-up was conducted to record the occurrence of recurrent intrauterine adhesions,oligomenorrhea,and amenorrhea in the two groups. Results:The total effective rate was 96.23%( 51/53) in the combination group,which was higher than that of 83.02%( 44/53) in the control group (P<0.05). The postoperative bleeding volume in the combination group was less than that in the control group (P<0.05),and the duration of bleeding,abdominal pain,and menstrual recovery time were shorter than those in the control group (P<0.05). After treatment, the endometrial thickness and uterine cavity volume in both groups increased compared to before treatment (P<0.05), and the endometrial thickness and uterine cavity volume in the combination group were both greater than those in the control group (P<0.05). After treatment,the RI and PI of the uterine arteries in both groups decreased compared to before treatment (P<0.05), and the RI and PI of the uterine arteries in the combination group were lower than those in the control group (P<0.05). The recurrence rate of intrauterine adhesions and the incidence of amenorrhea in the combination group were lower than those in the control group (P<0.05), and the pregnancy rate was higher than that in the control group (P<0.05). Conclusion: The Bushen Huoxue Prescription combined with TCRA significantly improves intrauterine adhesions treatment effects, which can accelerate postoperative recovery, improve uterine cavity morphology and uterine artery hemodynamics, reduce the risk of recurrence of intrauterine adhesions,and increase pregnancy rates.

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张庆,杜娟,朱玲玲.补肾活血方联合宫腔镜下宫腔粘连分离术治疗中重度宫腔粘连临床研究[J].新中医,2025,57(13):83-87

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  • 在线发布日期: 2025-07-14
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