葛根黑苏汤加减联合西药治疗肾虚血瘀型薄型子宫内膜不孕症临床研究
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R271

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温州市科技局项目(Y20211076)


Clinical Study on Modified Gegen Heisu Decoction Combined with Western Medicine for Thin Endometrial Infertility of Kidney-Deficiency and Blood Stasis Type
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    摘要:

    目的:观察葛根黑苏汤加减联合西药治疗肾虚血瘀型薄型子宫内膜不孕症(TEI) 的临床疗效。方 法:选择2023年2—12月浙江中医药大学附属温州市中医院中医妇科收治的108例肾虚血瘀型TEI患者,按随 机数字表法分为研究组和对照组各54例。对照组给予雌二醇片/雌二醇地屈孕酮片口服,研究组在对照组基础 上联合葛根黑苏汤加减治疗,连续治疗3个月经周期或确定妊娠时停药。比较2组治疗前后的子宫内膜厚度、 子宫内膜形态、子宫血流动力学指标[子宫动脉搏动指数(PI)、阻力指数(RI) ]和中医证候积分,比较治疗 结束后6个月内的妊娠率。结果:治疗后,2组子宫内膜均较治疗前增厚(P<0.05),研究组子宫内膜厚于对 照组(P<0.05)。2组子宫内膜形态均较治疗前改善(P<0.05),研究组子宫内膜形态优于对照组(P<0.05)。 2组子宫PI值、RI值及中医证候积分均较治疗前降低(P<0.05),研究组子宫PI值、RI值及中医证候积分均低 于对照组(P<0.05)。研究组妊娠率(59.61%,31/52) 高于对照组(38.46%,20/52)(P<0.05)。结论:葛根 黑苏汤加减联合西药治疗肾虚血瘀型TEI,可增加子宫内膜厚度和改善子宫内膜形态,调节子宫血流动力学, 提高妊娠率。

    Abstract:

    Abstract:Objective:To observe the clinical efficacy of modified Gegen Heisu Decoction combined with western medicine in treating thin endometrial infertility (TEI) of kidney-deficiency and blood stasis type. Methods:A total of 108 patients TEI of with kidney-deficiency and blood stasis type treated at the Department of Chinese Medicine Gynecology, Wenzhou TCM Hospital of Zhejiang Chinese Medical University from February to December 2023 were selected and divided into a study group and a control group,with 54 cases in each group,using a random number table method. The control group was given oral administration of Estradiol Tablets/Estradiol Dydrogesterone Tablets, while the study group received modified Gegen Heisu Decoction in addition to the treatment of the control group. The treatment was continued for three menstrual cycles or until pregnancy was confirmed. Before and after treatment,the endometrial thickness, endometrial morphology, and uterine hemodynamics indexes [uterine artery pulsatility index (PI) and resistance index (RI)], and traditional Chinese medicine (TCM) syndrome scores were compared between the two groups. And the pregnancy rates within six months after treatment were compared. Results: After treatment, the endometrial thickness was increased in both groups compared to before treatment (P<0.05), with the study group achieving a thicker endometrium than the control group (P<0.05). The endometrial morphology was improved in both groups compared to before treatment (P<0.05),with the study group showing better endometrial morphology than the control group (P<0.05). The PI and RI values of uterine artery and TCM syndrome scores were decreased in both groups compared to before treatment (P<0.05),with the study group achieving lower PI,RI values of uterine artery, and TCM syndrome scores than the control group (P<0.05). The pregnancy rate in the study group was 59.61% (31/ 52), higher than that in the control group at 38.46% (20/52) (P<0.05). Conclusion: Modified Gegen Heisu Decoction combined with western medicine can thicken endometrium, improve endometrial morphology, regulate uterine hemodynamics,and increase the pregnancy rate in patients with TEI of kidney-deficiency and blood stasis type.

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郑慧君,胡欣欣,潘鸿,高楚楚,李婷.葛根黑苏汤加减联合西药治疗肾虚血瘀型薄型子宫内膜不孕症临床研究[J].新中医,2025,57(13):92-96

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  • 在线发布日期: 2025-07-14
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