Abstract：Diabetes-related dry eye is a common ocular surface complication in clinical practice，characterized by highly complex pathogenesis， recurrence condition， and difficulty in achieving a complete cure， which negatively impacts patients' physical and mental health. This article integrates modern medical understanding and approaches of diabetes-related dry eye from the perspective of collateral theory. It proposes that the primary pathogenesis of diabetesrelated dry eye may involve collateral deficiency with malnutrition， collateral damage with toxin accumulation， and collateral stagnation. Therapeutic principles may focus on unblocking and tonifying to nourish collaterals， removing toxins to restore collaterals， and activiting qi and blood circulation to unblock collaterals， with nourishing yin and unblocking collaterals being consistently applied throughout the treatment.