基于现代文献分析幽门螺杆菌相关性溃疡中医证型分布规律及证素分布特征
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R259

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国家自然科学基金项目(82374429);湖南省自然科学基金项目(2023JJ30460);刘良院士工作站指导项目(22YS003);中华中医药学会青年人才托举工程项目(2024-QNRC2-B25);湖南省卫生健康高层次人才项目(20240304116)


Analysis of Chinese Medicine Syndrome Types and Syndrome Element Distribution in Helicobacter Pylori-Associated Ulcers Based on Modern Literature
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    摘要:

    目的:通过对幽门螺杆菌(Hp) 相关性溃疡临床研究文献进行分析,探讨本病的中医证型分布规 律及证素分布特征。方法:检索中国知网(CNKI)、维普、万方文献数据库1994—2024年有关Hp相关性溃疡 临床文献,对文献进行筛选,运用表格归纳整理,从病例来源、性别分布、证型及证素等方面对数据进行分 析,探讨Hp相关性溃疡的中医证型及证素分布特点及规律。结果:共纳入36篇文献,涉及Hp相关性溃疡患 者共5 731例,其中男性占61.39%,女性占38.61%,Hp相关性溃疡患病比例逐年上升,且该疾病全国均有分 布。Hp相关性溃疡中医证型按出现频率排序由高到低为脾胃湿热、脾胃虚弱(寒)、肝胃不和、肝胃郁热、脾 虚不摄、胃阴不足、胃络瘀阻、脾虚湿热、肝胃气滞、寒热错杂;中医病位证素分布按照出现频率由高到低排 序为胃、肝、脾,兼夹病位证素中以“脾、胃”为主;病性证素分布按照出现频率由高到低排序为热、湿、阳 虚、气滞、气虚、阴虚、血瘀,兼夹病性证素中以“湿、热”为主。广东文献中Hp相关性溃疡病例证型按由 高到低频率排序为脾胃湿热、脾虚湿热、脾虚不摄、脾胃虚弱(寒)、肝胃不和、肝胃郁热、胃络瘀阻、胃阴 不足、肝胃气滞;病位证素分布按频率由高到低排序为肝、胃、脾,兼夹病位证素中以“脾、胃”为主;病性 证素分布按频率由高到低排序为热、气虚、湿、气滞、阳虚、血瘀、阴虚,兼夹病性证素中以“湿、热”为 主。结论:Hp相关性溃疡中医证候分型存在一定的地域差异,最常见的证型是脾胃湿热,最常见的病性证素 是热,最常见的病位证素是胃。

    Abstract:

    Abstract: Objective: To explore the distribution patterns of Chinese medicine syndrome types and syndrome elements in Helicobacter pylori (Hp)-associated ulcers through analysis of clinical research literature. Methods: Clinical studies on Hp-associated ulcers published from 1994 to 2024 were retrieved from the CNKI, VIP, and Wanfang databases. Eligible literature was screened, tabulated, and analyzed for case sources, gender distribution, syndrome types, and syndrome elements. And the distribution patterns of Chinese medicine syndrome types and syndrome elements in Hp-associated ulcers were discussed. Results : A total of 36 pieces of literature involving 5 731 patients were included,with males accounting for 61.39% and females 38.61%. Hp-associated ulcer prevalence increased annually and distributed nationwide. Chinese medicine syndrome types,ranked by frequency,were:spleenstomach damp-heat, spleen-stomach deficiency (cold), liver-stomach disharmony, liver-stomach constraint heat, spleen deficiency failing to control, stomach yin insufficiency, stasis obstruction in the stomach collateral, spleen deficiency with damp-heat, liver-stomach qi stagnation, and cold-heat complex. Pathogenic location syndrome elements were predominantly the stomach, liver, and spleen, with "spleen and stomach" as the most common combination. Pathogenic nature syndrome elements,ranked by frequency,were:heat,dampness,yang deficiency, qi stagnation,qi deficiency,yin deficiency,and blood stasis,with "damp and heat" as the primary combination. In literature associated with Guangdong Province, syndrome types prioritized spleen-stomach damp-heat, spleen deficiency with damp-heat, spleen deficiency failing to control, spleen-stomach deficiency (cold), liver-stomach disharmony, liver-stomach constraint heat, stasis obstruction in the stomach collateral, stomach yin insufficiency, and liver-stomach qi stagnation; pathogenic location elements emphasized the liver, stomach, and spleen, with "spleen and stomach" as the most common combination,and pathogenic nature syndrome elements focused on heat,qi deficiency, dampness, qi stagnation, yang deficiency, blood stasis, and yin deficiency, with "damp and heat" remaining dominant. Conclusion: Chinese medicine syndrome types in Hp-associated ulcers exhibit regional variations. The most common syndrome type is spleen-stomach damp-heat, the most frequent pathogenic nature syndrome element is heat,and the most common pathogenic location syndrome element is the stomach.

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刘金坤,彭添凤,易美静,周宇轩,曾梅艳,宋厚盼.基于现代文献分析幽门螺杆菌相关性溃疡中医证型分布规律及证素分布特征[J].新中医,2025,57(13):164-172

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