Abstract： Objective： To explore the mechanism of action of Zuojin Pills in the treatment of gastroesophageal reflux disease （GERD） based on network pharmacology and molecular docking， and to predict potential therapeutic Chinese medicines. Methods： Effective components and targets of Zuojin Pills were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. The GERD disease targets were identified through GeneCards，OMIM，PharmGkb，TTD，and DrugBank databases to obtain potential targets for Zuojin Pills in treating GERD. A "active component-potential target" regulatory network was constructed using Cytoscape to screen key compounds. A protein-protein interaction （PPI） network of potential targets was built using the STRING database，and core targets were identified using Cytoscape software. The Gene Ontology （GO） functional and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway enrichment analyses were performed on potential targets. Molecular docking of key compounds with core targets was conducted using AutoDockTools. Potential therapeutic Chinese medicinals were predicted using Coremine Medical，and the Traditional Chinese Medicine Inheritance Computing Platform was used for classification statistics on the four natures， five flavors， meridian tropism， and therapeutic effects. Results： Key compounds identified included quercetin，isorhamnetin，evodiamine，β-sitosterol，berberine，and palmatine. Core targets included tumor protein 53 （TP53）， estrogen receptor 1 （ESR1）， serine/threonine kinase 1 （AKT1）， and tumor necrosis factor （TNF）. Core targets were mainly involved in biological processes such as response to xenobiotic stimulus，bacterial-derived molecules，and lipopolysaccharides，and were primarily enriched in pathways related to lipid and atherosclerosis， fluid shear stress and atherosclerosis， interleukin-17 （IL-17）， prostate cancer， and advanced glycation end products-receptor signaling pathways in diabetic complications. Key compounds showed good affinity for core targets. Poria and Ginseng Radix et Rhizoma， among other Chinese medicinals， have significant potential therapeutic value. Potential therapeutic Chinese medicinals are mostly bitter and cold heat-clearing herbs， primarily entering the liver meridian. Conclusion： Multiple effective components of Zuojin Pills can act on various potential targets and exert therapeutic effects on GERD through multiple pathways. Chinese medicinals such as Poria and Ginseng Radix et Rhizoma have potential therapeutic value in the treatment of GERD.