基于数据挖掘技术分析外用中成药治疗跌打损伤用药规律
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R274

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广东省基础与应用基础研究基金省企联合项目(2021A1515220133);广东省医学科学技术研究基金项目(B2022100);中山市科技创新领军人才资质项目(LJ2023001);中山市社会公益与基础研究项目(2020B1058)


Analysis of Medication Rules in Topical Chinese Patent Medicines for Traumatic Injuries Based on Data Mining Techniques
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    摘要:

    目的:基于数据挖掘技术分析国家药品监督管理局备案的治疗跌打损伤外用中成药的用药规律。 方法:筛选出国家药品监督管理局备案(截止2024年3月31日) 的治疗跌打损伤的外用中成药,运用Excel 2010工作表统计纳入药物的使用频次、功效、四气、五味、归经等信息,利用SPSS Modeler 18.0软件进行关联 规则分析、运用Origin 2021进行聚类分析、使用Cytoscape3.10.1软件制作关联复杂网络图。结果:纳入的外用 中成药处方102首,共纳入药物330种。药物总使用频次为1 393次,使用频次≥11次的药物有34种,包括冰 片、樟脑、当归等。四气以温为主,五味以辛、苦、甘为主,归经以肝、脾、心、肺、肾为主。关联强度最高 的药物组合为乳香-没药,聚类分析可得6类药物,复杂网络分析可知天然冰片、樟脑、薄荷脑之间形成了三 角强链接;乳香和没药,以及红花和当归之间存在较强链接。结论:治疗跌打损伤的外用中成药组方功效以开 窍醒神、活血化瘀为主,核心药物为促进透皮吸收药和活血化瘀药。

    Abstract:

    Abstract:Objective:To analyze the medication rules of topical Chinese patent medicines for traumatic injuries registered with the National Medical Products Administration using data mining techniques. Methods:Topical Chinese patent medicines for traumatic injuries registered with the National Medical Products Administration (as of March 31, 2024) were selected. Excel 2010 was used to compile statistics on the frequency of use,efficacy,four qi,five flavors, and meridian entry of the included medicines. SPSS Modeler 18.0 was utilized for association rule analysis, Origin 2021 for cluster analysis , and Cytoscape 3.10.1 for creating complex network diagrams. Results : A total of 102 prescriptions for topical Chinese patent medicines were included, encompassing 330 medicines. The total frequency of use was 1 393 times, with 34 medicines used 11 times or more, including Borneolum Syntheticum, Camphor and Angelicae Sinensis Radix. The four qi were predominantly warm,the five flavors were mainly pungent, bitter, and sweet, and the meridian entries were primarily liver, spleen, heart, lung, and kidney. The strongest association was found between Olibanum and Myrrha. Cluster analysis identified six categories of medicines, and complex network analysis revealed a strong triangular link among Borneolum Syntheticum (Natural),Camphor and LMenthol; strong links were also observed between Olibanum and Myrrha, as well as Carthami Flos and Angelicae Sinensis Radix. Conclusion: The prescriptions of topical Chinese patent medicines for traumatic injuries primarily focus on opening orifices and reviving the spirit, and promoting blood circulation to remove blood stasis. The core medicines are those that enhance transdermal absorption and promote blood circulation to remove blood stasis.

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刘卓华,陈亮,陈诚霖.基于数据挖掘技术分析外用中成药治疗跌打损伤用药规律[J].新中医,2025,57(14):1-6

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  • 在线发布日期: 2025-07-26
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