Abstract：Objective：To analyze the medication rules of Professor DU Shaohui in treating insomnia based on data mining. Methods： The medical records of Professor DU in treating insomnia in the outpatient department from September 1，2022 to September 1，2024 were collected. Excel was used to count the frequency，four qi，five flavors， meridian entries，effect and other data of Chinese medicinals. R programming software was used for cluster analysis and association rule analysis， and visual tools were used to analyze the relationship between Chinese medicinals and prescription rules. Results：A total of 212 medical cases were included，involving 187 kinds of Chinese medicinals， and the total frequency was 2 918 times. According to the frequency analysis，there were 32 kinds of Chinese medicinals with frequency ≥ 30，and the top five were Glycyrrhizae Radix et Rhizoma，Chuanxiong Rhizoma，Pinelliae Rhizoma Praeparatum，Atractylodis Macrocephalae Rhizoma and Puerariae Lobatae Radix；the main meridian entries were the foot-Taiyin spleen meridian， foot-Jueyin liver meridian and hand-Taiyin lung meridian； the medicinal nature was mainly warm；the flavors were mainly pungent and sweet；the effect was mainly for supplementing deficiency，followed by clearing heat and releasing the exterior. The core medicinal pairs and medicinal groups，17 in total，were obtained by association rule analysis. Among them， the core medicinal pairs were Puerariae Lobatae Radix-Chuanxiong Rhizoma， Scutellariae Radix-Pinelliae Rhizoma Praeparatum， Ostreae Concha-Pinelliae Rhizoma Praeparatum， Puerariae Lobatae Radix-Pinelliae Rhizoma Praeparatum， Bupleuri Radix-Pinelliae Rhizoma Praeparatum， etc. the core medicinal group was Pinelliae Rhizoma Praeparatum-Puerariae Lobatae Radix-Chuanxiong Rhizoma. Four medicinal combinations were obtained by cluster analysis. Conclusion： Professor DU commonly uses Chinese medicinals for supplementing deficiency in the treatment of insomnia，as well as those for heat-clearing and exteriorreleasing. The Chinese medicinals are combined by Chaige method， Lizhong method， Fuzi method and Jianzhong method，which reflects the treatment method of yin-yang confluence from six qi and root and branch by simultaneous wind-fire neutralization，dryness-dampness equilibrium，and ying-wei harmonization.