Abstract：Objective：To observe the clinical effect of the combination use of Shenmai Injection and Megiumine Adenosine Cyclophosphate for Injection on chronic heart failure （CHF） of dual deficiency of qi and yin type. Methods： A total of 100 CHF patients of dual deficiency of qi and yin type admitted to Deqing People's Hospital from January 2023 to June 2024 were included and divided into the western medicine group and the combination group according to the random number table method，with 50 cases in each group. The western medicine group was treated with Megiumine Adenosine Cyclophosphate for Injection，and the combination group was treated with Shenmai Injection combined with Megiumine Adenosine Cyclophosphate for Injection. Both groups were treated for 14 days. The clinical effects， and cardiac function indexes，heart failure markers，exercise endurance，quality of life and safety indexes before and after treatment were respectively compared between the two groups. Results：After treatment，the total effective rate of the combination group was 84.00% （42/50），which was higher than that of the western medicine group [62.00% （31/50）]， with a statistically significant difference （P＜0.05）. The left ventricular ejection fraction （LVEF） in the two groups was elevated when compared with that before treatment，and the LVEF in the combination group was higher than that in the western medicine group，with statistically significant differences （P＜0.05）. The left ventricular mass index （LVMI） in the two groups was reduced when compared with that before treatment，and LVMI in the combination group was lower than that in the western medicine group，with statistically significant differences （P＜0.05）. The levels of N-terminal B-type natriuretic peptide （NT-proBNP） and cardiac troponin T （cTnT） in the two groups were decreased when compared with those before treatment，and the levels of NT-proBNP and cTnT in the combination group were lower than those in the western medicine group， with statistically significant differences （P＜0.05）. The 6-minute walking test（ 6MWT） distance in both groups was longer than that before treatment，and the 6MWT distance in the combination group was longer than that in the western medicine group， with statistically significant differences （P＜0.05）. The scores of Minnesota Living with Heart Failure Questionnaire （MLHFQ） in the two groups were down-regulated when compared with those before treatment， and the MLHFQ score in the combination group was lower than that in the western medicine group，with statistically significant differences （P＜0.05）. There was no significant difference being found in the comparisons of the levels of creatinine （Cr）， estimated glomerular filtration rate （eGFR）， alanine aminotransferase（ ALT） and albumin（ Alb） between the two groups before and after treatment（ P＞0.05）. Conclusion： The combination use of Shenmai Injection and Megiumine Adenosine Cyclophosphate for Injection has a significant curative effect on CHF of dual deficiency of qi and yin type， which can alleviate ventricular remodeling， improve cardiac function，enhance exercise endurance and quality of life，and has good safety.