Abstract： Objective： To observe the clinical efficacy of Yinao Wendan Decoction in the treatment of mild cognitive impairment （MCI）. Methods： A total of 70 patients with MCI who admitted to the outpatients of Memory Disorders Clinic and hospitalized in Geriatrics Department of Higher Education Mega Center Hospital， Guangdong Provincial Hospital of Chinese Medicine were selected from December 2022 to July 2024， and were divided into 35 cases each in the control group and the study group according to the random number table method. The control group was given oral administration of Donepezil Hydrochloride Tablets，and the study group was treated with Yinao Wendan Decoction. After 12 weeks of treatment，the clinical efficacy in the two groups was compared，as well as the changes in the scores of the Mini-Mental State Examination （MMSE），Montreal Cognitive Assessment （MoCA），and Activities of Daily Living Scale （ADCS-ADL） before and after treatment. Results： After treatment， the total effective rate was 80.00% （28/35） in the study group and 57.14% （20/35） in the control group， the difference being statistically significant （P＜0.05）. After treatment， the scores of MMSE and MoCA in the two groups were increased when compared with those before treatment （P＜0.05）， the ADCS-ADL score in the study group was increased when compared with that before treatment （P＜0.05），and the scores of MMSE，MoCA，and ADCS-ADL in the study group were higher than those in the control group （P＜0.05）. The Cibic-plus scores in the two groups were decreased when compared with those before treatment （P＜0.05），and the Cibic-plus score in the study group was lower than that in the control group （P＜0.05）. Conclusion： Yinao Wendan Decoction in the treatment of MCI can enhance the clinical efficacy， improve the cognitive function and activities of daily living of patients， and the effect is superior to that of Donepezil treatment.