Abstract：Objective：To observe the clinical effect of using Qingyi Jiedu Decoction by nasal feeding combined with continuous blood purification （CBP） on the basis of conventional symptomatic therapy for the treatment of severe acute pancreatitis （SAP） of stasis and toxin accumulation type. Methods：The subjects were 108 SAP patients of stasis and toxin accumulation type admitted to Hangzhou TCM Hospital of Zhejiang Chinese Medical University from May 2022 to May 2024. They were divided into the study group and the control group using the random number table method， with 54 patients in each group. Both groups received routine symptomatic treatment；the control group received CBP， and the study group received Qingyi Jiedu Decoction by nasal feeding combined with CBP. Both groups were treated for two weeks. The following indexes were evaluated before and after treatment： the traditional Chinese medicine syndrome scores，Acute Physiology and Chronic Health Evaluation （APACHE-Ⅱ scores），serum inflammatory factors [high-sensitivity C-reactive protein （hs-CRP）， procalcitonin （PCT）， interleukin-6 （IL-6）， tumor necrosis factor alpha （TNF- α）]， intestinal mucosal barrier function indicators [endotoxin（ETX）， diamine oxidase （DAO）， Dlactate （D-LAC）]， and pancreatic exocrine function indicators [amylase （AMY）， lipase （LPS）] levels. The clinical effects in the two groups were compared as well. Results：After treatment，the total effective rate was 92.31%（48/52） in the study group， higher than that in the control group （78.43%， 40/51）， the difference being significant （P＜ 0.05）. The traditional Chinese medicine syndrome scores and APACHE-Ⅱ scores in both groups were decreased when compared with those before treatment （P＜0.05）；the traditional Chinese medicine syndrome scores and APACHE-Ⅱ scores in the study group were lower than those in the control group （P＜0.05）. The levels of hs-CRP，PCT，IL-6， TNF-α，ETX，DAO，D-LAC，AMY，and LPS in both groups of serum were decreased when compared with those before treatment （P＜0.05）， and the above nine levels in the study group were lower than those in the control group （P＜0.05）. Conclusion：On the basis of conventional symptomatic therapy，the use of Qingyi Jiedu Decoction by nasal feeding combined with CBP can improve the effect of treating severe acute pancreatitis of stasis and toxin accumulation type. It has a positive effect on relieving clinical symptoms， alleviating the condition， improving intestinal mucosal barrier function and pancreatic exocrine function.