Abstract： Objective： To analyze the distribution of Chinese medicine syndrome elements and medication patterns in Guillain-Barré syndrome using data mining technology. Methods： By searching the China National Knowledge Infrastructure （CNKI）， Wanfang Database， Chinese Science and Technology Journal Database（VIP）， PubMed，Web of Science，and Embase，a database of Chinese medicine syndrome elements and Chinese medicinals for Guillain-Barré syndrome was established. Relational network graphics，association rule，and cluster analyses were performed on high-frequency Chinese medicinals. Results：A total of 27 articles were included，involving 37 Chinese medicinal prescriptions. Frequency analysis identified 4 location of syndrome elements and 12 nature of syndrome elements. The top 3 most frequent location of syndrome elements were the spleen，kidney，and liver，while the top 4 most frequent nature of syndrome elements were qi deficiency， blood stasis， dampness， and heat. A total of 103 Chinese medicinals were used to treat this disease， with a cumulative frequency of 371 times. The top 5 most frequently used medicinals were Astragali Radix，Angelicae Sinensis Radix，Glycyrrhizae Radix et Rhizoma，Paeoniae Radix Alba， and Chuanxiong Rhizoma. There were 22 high-frequency medicinals with a usage frequency of ≥ 5 times， which were classified into 15 categories of therapeutic effects， with the top 5 being tonifying qi， activating blood and resolving stasis， diuretic and dampness-eliminating， clearing heat and cooling blood， and nourishing blood and activating blood. In the association analysis，there were 10 qualified two-item medicinal combinations and 21 qualified three-item medicinal combinations. Cluster analysis yielded 3 new prescription combinations. Conclusion：The main disease locations of Guillain-Barré syndrome are in the spleen，kidney，and liver，characterized as a deficiency at the root and excess at the manifestation， with qi deficiency as the root and dampness， heat， and blood stasis as the manifestations. The treatment is based on tonifying qi，supplemented by activating blood，eliminating dampness，and clearing heat and dampness.