Abstract： Objective： To observe the clinical effect of Qingjin Huatan Decoction combined with acupoint application in treating patients with acute exacerbation phase of chronic obstructive pulmonary disease （AECOPD） with phlegm-heat accumulation in lung syndrome based on conventional symptomatic therapy. Methods ： A total of 200 AECOPD patients with phlegm-heat accumulation in lung syndrome treated in the Department of Pulmonary Diseases at Jinhua Hospital of Traditional Chinese Medicine from February 2022 to February 2024 were selected. They were divided into the control group and the study group using a random number table method，with 100 cases in each group. The control group received conventional symptomatic therapy， while the study group received additional treatment with Qingjin Huatan Decoction combined with acupoint application. Both groups were treated for 14 days. Clinical effects，traditional Chinese medicine syndrome scores，blood gas parameters，immune function indexes，and serum inflammatory markers between the two groups were compared before and after treatment. Results： After treatment， the total effective rate was significantly higher in the study group （93.68%， 89/95） than in the control group （83.70%，77/92） （P＜0.05）. All traditional Chinese medicine syndrome scores decreased significantly in both groups after treatment （P＜0.05），with lower scores observed in the study group compared to the control group （P＜ 0.05）. After treatment，blood gas analysis showed that arterial partial pressure of oxygen （PaO2） increased （P＜0.05） and arterial partial pressure of carbon dioxide （PaCO2） decreased in both groups （P＜0.05）. The study group exhibited higher PaO2 and lower PaCO2 than the control group （P＜0.05）. Regulatory T cells （Treg） in serum increased significantly in both groups compared to those before treatment （P＜0.05），with higher levels in the study group （P＜ 0.05）. Helper T cells 17 （Th17） in serum decreased significantly in both groups （P＜0.05），with lower levels in the study group （P＜0.05）. Levels of procalcitonin （PCT），C-reactive protein （CRP），interleukin-6（ IL-6），and tumor necrosis factor-α （TNF-α） in serum decreased significantly in both groups （P＜0.05），with lower levels in the study group （P＜0.05）. Conclusion： Qingjin Huatan Decoction combined with acupoint application treated AECOPD patients with phlegm-heat accumulation in lung syndrome improves ventilation function， reduces systemic inflammation，regulates immune function，alleviates clinical symptoms，and enhances overall therapeutic outcomes.