Abstract：Objective：To observe the clinical effect of Chinese medicine comprehensive therapy combined with Celecoxib on knee osteoarthritis （KOA） during episode period with damp-heat obstruction syndrome. Methods：From October 2022 to May 2024，116 cases of KOA patients during episode period with damp-heat obstruction syndrome， who were treated at the Chinese medicine Department of Hangzhou Xiacheng District Integrated Chinese and Western Medicine Hospital，were divided into the control group and the combination group according to the random number table method，with 58 cases in each group. The control group was given the oral administration of Celecoxib Capsules，and the combination group was additionally given Chinese medicine comprehensive therapy，including external application of Ruyi Jinhuang Powder Ointment，tuina，and traction-manipulation，in addition to the treatment given to the control group. Both groups were treated for two weeks. Clinical effects， and time to pain relief and pain resolution were compared between the two groups. The knee pain severity， Western Ontario and McMaster Universities Osteoarthritis Index （WOMAC）， Lequesne indexes， traditional Chinese medicine syndrome scores， and levels of inflammatory factors [tumor necrosis factor-α （TNF-α），interleukin （IL）-1β，and IL-6] before and after treatment were compared between the two groups. Results：After two weeks of treatment，the Visual Analogue Scale（ VAS） scores for knee joint pain in the two groups were decreased when compared with those before treatment （P＜0.05）， with the combination group showing lower scores than the control group （P＜0.05）；the combination group had shorter time to pain relief and pain resolution compared to the control group （P＜0.05）. The WOMAC and Lequesne indexes scores in the two groups were decreased when compared with those before treatment （P＜0.05）， with the combination group showing lower scores than the control group （P＜0.05）. The scores of main symptoms，secondary symptoms，and overall assessment in the two groups were decreased （P＜0.05）， with the combination group showing lower scores than the control group （P＜0.05）. The levels of TNF-α，IL-1β，and IL-6 in the two groups were reduced when compared with those before treatment （P＜0.05），with the combination group showing lower levels than the control group （P＜0.05）. The total effective rate in the combination group was 92.45% （49/53）， higher than 77.55% （38/49） in the control group （P＜0.05）. Conclusion： Chinese medicine comprehensive therapy combined with Celecoxib for KOA during episode period with damp-heat obstruction syndrome can relieve pain and improve knee joint function， shorten the duration of the episode period， and inhibit inflammatory responses. The clinical efficacy is superior to that of antiinflammatory and analgesic treatment with western medicine alone.