Abstract： Objective： To observe the curative effect of Jianpi Yifei Prescription in promoting the postoperative rehabilitation of patients with non-small cell lung cancer， as well as its influence on the quality of life and immune function. Methods： A total of 100 patients with non-small cell lung cancer who underwent total thoracoscopic lobectomy in Taizhou Central Hospital from September 2021 to September 2023 were selected as the research subjects， and they were divided into the control group and the observation group according to the random number table method， with 50 cases in each group. The control group was given conventional adjuvant chemotherapy three weeks after surgery， and the observation group was treated with Jianpi Yifei Prescription on the basis of the control group three weeks after surgery. Both groups were treated for six months. The pulmonary function，quality of life，immune function indexes and traditional Chinese medicine syndrome scores of the two groups before and after treatment were compared. Results： After treatment，the forced expiratory volume in the first second （FEV1），forced vital capacity（ FVC），and FEV1/FVC levels of the two groups were higher than those before treatment （P＜0.05）， and the FEV1， FVC， and FEV1/FVC levels of the observation group were higher than those of the control group （P＜0.05）. After treatment， the levels of CD3+ and CD4+ in the two groups were higher than those before treatment （P＜0.05），and the level of CD8+ was lower than that before treatment （P＜0.05）；the levels of CD3+ and CD4+ in the observation group were higher than those in the control group，and the level of CD8+ was lower than that in the control group （P＜0.05）. After treatment，the scores of various indexes of the quality of life in the two groups were higher than those before treatment （P＜0.05），and the scores of various indexes of the quality of life in the observation group were higher than those in the control group （P＜ 0.05）. After treatment，the scores of various traditional Chinese medicine syndromes in the two groups were lower than those before treatment （P＜0.05），and the scores of various traditional Chinese medicine syndromes in the observation group were lower than those in the control group （P＜0.05）. Conclusion： Jianpi Yifei Prescription can promote the postoperative recovery of patients with non-small cell lung cancer through the synergistic effect of multiple targets，and can improve the scores of traditional Chinese medicine syndromes， the quality of life and the immune function of patients.