Abstract：There is a strong relationship between the theory of kidney generates marrow and the neuro-endocrineimmune system and the core connotation lies in kidney essence transforming and generating bone marrow and brain marrow. In the aspect of kidney essence generating bone marrow，kidney-tonifying formulas and medicinals can regulate the fine substances in the marrow through multiple pathways and targets，promote osteogenic differentiation，regulate hematopoietic function and fat metabolism，and lay a material foundation for children's growth through three aspects， including tonifying kidney to generate bone marrow and bone，tonifying kidney and clearing lipid to generate bone and tonifying kidney and filling marrow to transform blood. In terms of kidney essence generating brain marrow， kidneytonifying formulas and medicinals can regulate the immune response of the central nervous system by the two-way regulatory mechanism between the marrow and the brain，thus affecting bone development and homeostasis. In clinical practice，using kidney-tonifying formulas and medicinals by syndrome differentiation and caution has a certain curative effect on children with precocious puberty，reflecting the possibility of its effect on marrow. This paper is grounded in the theory of kidney generates marrow in Chinese medicine，positing that marrow serves as a crucial intermediary in the kidney-brain connection. It is suggested that kidney-tonifying formulas and medicinals may affect the brain and further regulate children’s growth and development by the regulation of treatment targets centered on marrow so that the occurrence of each link is preceded by alterations in the marrow.